Non-Motor Symptoms as Markers of Disease Severity in Parkinson's Disease: Associations Between Constipation, Depression, REM Sleep Behavior Disorder, and Motor Impairment.

João Paulo Mota Telles, Júlia Haddad Labello, Lucas Camargo, Carla Pastora-Sesin, Anna Carolyna Gianlorenço, Felipe Fregni

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In one paragraph

Article in Biomedicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Associations Between Sleep and Non-Motor Symptoms in RBD-Screened Suspected Prodromal Parkinson's Disease with Hyposmia or Orthostatic Hypotension.Journal of clinical medicine · 2026
Article
Efficacy of acupuncture for patients with Parkinson's disease-related constipation: study protocol for a randomized controlled, double-blind trial.Frontiers in neuroscience · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

João Paulo Mota TellesDepartment of Neurology, University of São Paulo, São Paulo 05403-010, Brazil.ORCID 0000-0001-9322-0405

Júlia Haddad LabelloDepartment of Neurology, University of São Paulo, São Paulo 05403-010, Brazil.

Lucas CamargoSpaulding Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-4112-6473

Carla Pastora-SesinSpaulding Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0009-0009-3624-5185

Anna Carolyna GianlorençoSpaulding Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-7334-3835

Felipe FregniSpaulding Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital, Harvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-1703-7526

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

anosmiaconstipationdepressionParkinson diseaseREM sleep behavior disorder

Identifiers

PMID41301797

DOI10.3390/biomedicines13112704

PMCPMC12650078

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.