Evidence map›Paper›PMID 41301617›Full record

ArticleAntibiotics (Basel, Switzerland)2025

ElastoMeric Infusion Pumps for Hospital AntibioTICs (EMPHATIC): A Feasibility Study.

Joseph J Spencer-Jones, Stuart E Bond, Nicola Walker, Jade Lee-Milner, Julie Thompson, Damilola Mustapha, Annam Sadiq, Achyut Guleri, Jayanta B Sarma, Liz Breen and 1 more

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Joseph J Spencer-JonesMid Yorkshire Teaching NHS Trust, Wakefield WF1 4DG, UK.
Stuart E BondMid Yorkshire Teaching NHS Trust, Wakefield WF1 4DG, UK.ORCID 0000-0001-9640-2474
Nicola WalkerMid Yorkshire Teaching NHS Trust, Wakefield WF1 4DG, UK.
Jade Lee-MilnerMid Yorkshire Teaching NHS Trust, Wakefield WF1 4DG, UK.ORCID 0000-0002-9588-9433
Julie ThompsonMid Yorkshire Teaching NHS Trust, Wakefield WF1 4DG, UK.
Damilola MustaphaMid Yorkshire Teaching NHS Trust, Wakefield WF1 4DG, UK.
Annam SadiqMid Yorkshire Teaching NHS Trust, Wakefield WF1 4DG, UK.
Achyut GuleriMid Yorkshire Teaching NHS Trust, Wakefield WF1 4DG, UK.
Jayanta B SarmaMid Yorkshire Teaching NHS Trust, Wakefield WF1 4DG, UK.
Liz BreenSchool of Pharmacy & Medicinal Sciences, Faculty of Life Sciences, University of Bradford, Bradford BD7 1DP, UK.
Jonathan A T SandoeSchool of Medicine, Faculty of Medicine and Health, The University of Leeds, Worsley Building, Leeds LS2 9JT, UK.ORCID 0000-0003-0193-8677

Funding

Mid Yorkshire Teaching Trust Charitable Funds CFA0030
6 · The paper itself

Abstract

backgroundElastomeric infusion pumps (EMPs) are safe and effective for administering outpatient intravenous (IV) antibiotics. We hypothesized that EMPs may provide benefits in the inpatient setting. This study aimed to assess the feasibility of giving IV antibiotics using EMPs to adult inpatients and to identify barriers and facilitators for their implementation. METHODS AND

objectivesPatients who were 18 years of age and over requiring at least seven days of IV flucloxacillin, benzylpenicillin or piperacillin/tazobactam and who were clinically stable were eligible. We collected quantitative data for feasibility, clinical outcomes and intervention acceptability. We applied an implementation research framework to help triangulate the data. Analyses were descriptive, with the intent of preparing for future studies.

resultsIV antibiotics from 94 EMPs were administered to nine patients, with five patients completing treatment with an EMP. Five of the six patients surveyed said they would use EMPs again. Nurses felt EMPs were safer, less time consuming and improved working conditions. IV antibiotics via EMPs cost GBP 32.50 (GBP 3.35-GBP 83.44) more per day than intermittent infusions. Residual volume in EMPs was an issue which resulted in reduced antibiotic doses being delivered. The main facilitators to use of EMPs in the inpatient setting were adaptability, tension for change, recipient centeredness and needs of the deliverers. The barriers were lack of advantage, critical incidents and cost.

conclusionThis proof of concept feasibility study shows that it may be feasible to use EMPs in the inpatient setting. There is potential to improve patient and staff experience; however, cost and residual volume are potential barriers to implementation, with further studies required.

Indexed as

antibioticsantibiotic therapybenzylpenicillinbeta-lactamselastomericflucloxacillininpatientintravenouspiperacillin/tazobactam

Identifiers

PMID41301617
PMCPMC12649511

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.