Toll-like Receptor 7 Deficiency Attenuates Platelet Dysfunction in Sepsis.

Rashida Mohamed-Hinds, Arijit Dutta, Chanhee Park, Xiaomei Yang, Lin Zou, Wei Chao, Brittney Williams

Abstract read

In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

The Platelet-Virus Axis in Human Disease.Viruses · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rashida Mohamed-HindsTranslational Research Program, Department of Anesthesiology, Center for Shock, Trauma and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0009-0008-4808-6284

Arijit DuttaTranslational Research Program, Department of Anesthesiology, Center for Shock, Trauma and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0009-0002-3209-8391

Chanhee ParkTranslational Research Program, Department of Anesthesiology, Center for Shock, Trauma and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Xiaomei YangTranslational Research Program, Department of Anesthesiology, Center for Shock, Trauma and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-4081-4207

Lin ZouTranslational Research Program, Department of Anesthesiology, Center for Shock, Trauma and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Wei ChaoTranslational Research Program, Department of Anesthesiology, Center for Shock, Trauma and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-2505-1360

Brittney WilliamsTranslational Research Program, Department of Anesthesiology, Center for Shock, Trauma and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

Funding

National Heart Lung and Blood Institute K08HL153784-

6 · The paper itself

Abstract

Sepsis is a clinical syndrome caused by abnormal host response to infection. Thrombocytopenia and platelet dysfunction are common findings in sepsis and associated with worse outcomes. The innate immune single-stranded RNA sensor, Toll-like Receptor-7 (TLR7), plays a key role in thrombocytopenia in sepsis. This study investigated whether TLR7 signaling also contributes to platelet dysfunction in sepsis, and whether the bioactivity of downstream inflammatory mediators, specifically extracellular vesicles (EVs), is impacted by the TLR7 signaling pathway. Sepsis was induced in wild-type (WT) and TLR7-deficient (TLR7

Indexed as

Blood PlateletsMembrane GlycoproteinsSepsisToll-Like Receptor 7AnimalsCalcium SignalingExtracellular VesiclesMaleMiceMice, Inbred C57BLMice, KnockoutPlatelet AggregationSignal TransductionMembrane GlycoproteinsTlr7 protein, mouseToll-Like Receptor 7extracellular vesiclesinflammationplateletssepsissepsis-induced platelet dysfunctionToll-like receptor 7

Identifiers

PMID41301522

DOI10.3390/biom15111604

PMCPMC12650191

What OpenQuestion holds

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LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.