Evidence map›Paper›PMID 41301467›Full record

ArticleBiomolecules2025

Bullous Pemphigoid Develops Independently of DAP12.

Manuela Pigors, Sabrina Patzelt, Maëlys Brudey, Shirin Emtenani, Stanislav Khil'chenko, Mayumi Kamaguchi, Niklas Reichhelm, Melissa Parker, Katja Bieber, Ralf J Ludwig and 1 more

Abstract read
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In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Manuela PigorsLübeck Institute of Experimental Dermatology, University of Lübeck, 23562 Lübeck, Germany.ORCID 0000-0002-3226-3935
Sabrina PatzeltLübeck Institute of Experimental Dermatology, University of Lübeck, 23562 Lübeck, Germany.ORCID 0000-0002-1172-3015
Maëlys BrudeyLübeck Institute of Experimental Dermatology, University of Lübeck, 23562 Lübeck, Germany.
Shirin EmtenaniLübeck Institute of Experimental Dermatology, University of Lübeck, 23562 Lübeck, Germany.ORCID 0000-0002-7965-8045
Stanislav Khil'chenkoLübeck Institute of Experimental Dermatology, University of Lübeck, 23562 Lübeck, Germany.
Mayumi KamaguchiLübeck Institute of Experimental Dermatology, University of Lübeck, 23562 Lübeck, Germany.
Niklas ReichhelmLübeck Institute of Experimental Dermatology, University of Lübeck, 23562 Lübeck, Germany.
Melissa ParkerIncyte Research Institute, Wilmington, DE 19803, USA.
Katja BieberLübeck Institute of Experimental Dermatology, University of Lübeck, 23562 Lübeck, Germany.ORCID 0000-0002-3855-6683
Ralf J LudwigLübeck Institute of Experimental Dermatology, University of Lübeck, 23562 Lübeck, Germany.
Enno SchmidtLübeck Institute of Experimental Dermatology, University of Lübeck, 23562 Lübeck, Germany.

Funding

Deutsche Forschungsgemeinschaft CRC1526 Pathomechanisms of Antibody-mediated AutoimmunityDeutsche Forschungsgemeinschaft CRU303 Pemphigoid DiseasesDeutsche Forschungsgemeinschaft DFG EXC 2167/1, TI-3Incyte (United States) n.a.University of Lübeck H01-2023
6 · The paper itself

Abstract

The adaptor molecule DNAX-activating protein of 12 kDa (DAP12) is broadly expressed in innate immune cells, but its role in autoimmunity remains unclear due to its dual regulatory functions. We investigated the contribution of the DAP12 pathway to bullous pemphigoid (BP), the most common autoimmune blistering disease, using a mouse model induced by transfer of anti-type XVII collagen (Col17) IgG. Repeated anti-Col17 IgG injections over 12 days produced comparable disease activity in DAP12-deficient and wildtype mice (

Indexed as

Adaptor Proteins, Signal TransducingMembrane ProteinsPemphigoid, BullousAnimalsAutoantigensCollagen Type XVIIDisease Models, AnimalImmunoglobulin GMembrane GlycoproteinsMiceMice, Inbred C57BLMice, KnockoutNon-Fibrillar CollagensReceptors, ImmunologicSignal TransductionSkinAdaptor Proteins, Signal TransducingAutoantigensCollagen Type XVIIImmunoglobulin GMembrane GlycoproteinsMembrane ProteinsNon-Fibrillar CollagensReceptors, ImmunologicTrem2 protein, mouseTyrobp protein, mouseautoimmune blistering diseasebasement membrane zoneparsaclisibPI3KTREM1TREM2type XVII collagentyrobp

Identifiers

PMID41301467
PMCPMC12650061

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.