Evidence map›Paper›PMID 41301445›Full record

ArticleBiomolecules2025

Efficient Mining and Characterization of Two Novel Keratinases from Metagenomic Database.

Jue Zhang, Guangxin Xu, Zhiwei Yi, Xixiang Tang

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jue ZhangKey Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361006, China.ORCID 0009-0002-6116-7253
Guangxin XuKey Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361006, China.
Zhiwei YiKey Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361006, China.ORCID 0000-0002-9460-5785
Xixiang TangKey Laboratory of Marine Genetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361006, China.

Funding

Fujian Provincial Natural Science Foundation of China 2021J02015National Key R\&D Program of China 2024YFC2815900Scientific Research Foundation of Third Institute of Oceanography SOA: 2017002Xiamen Southern Oceanographic Center 23CZB005HJ08
6 · The paper itself

Abstract

Keratin is a fibrous structural protein found in various natural materials such as hair, feathers, and nails. Its high stability and cross-linked structure make it resistant to degradation by common proteases, leading to the accumulation of keratinous waste in various industries. In this study, we developed and validated an effective bioinformatics-driven strategy for mining novel keratinase genes from the Esmatlas (ESM Metagenomic Atlas) macrogenomic database. Two candidate genes,

Indexed as

MetagenomeMetagenomicsPeptide HydrolasesAmino Acid SequenceAnimalsDatabases, GeneticData MiningEnzyme StabilityFeathersKeratinsKineticsPhylogenySubstrate SpecificitykeratinaseKeratinsPeptide Hydrolasesenzymatic characterizationkeratinasemetagenomicsstructural prediction

Identifiers

PMID41301445
PMCPMC12650211

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.