ArticleBioengineering (Basel, Switzerland)2025
Multiscale Coronary Arterial Network Generation and Hemodynamics Using Patient-Specific Fractional Myocardial Blood Volume.
Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Hierarchy Aware CT-Driven Constrained Constructive Optimization: A Framework for Coronary Network Generation.Annals of biomedical engineering · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
Ischemic heart disease (IHD) is the leading cause of death worldwide. Although 90% of the intramyocardial blood volume resides in the microvasculature, clinical imaging methods cannot visualize the microvascular coronary network in vivo, and non-invasive hemodynamic estimates overlook patient-specific microcirculatory contributions. Herein, we present a multiscale framework to extend the epicardial coronary tree and generate 1D microvascular networks in the myocardium based on ferumoxytol-enhanced magnetic resonance coronary imaging and fractional myocardial blood volume (fMBV) maps. Synthetic arterial networks were constructed from MRI data belonging to three swine, four healthy volunteers, and one IHD patient using a modified multistage, adaptive constrained constructive optimization approach. Hemodynamic simulations were performed in synthetic arterial networks. Morphological parameters were compared with empirical models. In 126 arterial networks (
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