Evidence map›Paper›PMID 41301184›Full record

ArticleBioengineering (Basel, Switzerland)2025

Anterior Cruciate Ligament Reconstruction Rehabilitation as a Complex Adaptive Process: From Control-Chaos to Actionable Return-to-Sport Decisions.

Georgios Kakavas, Nikoloaos Malliaropoulos, Florian Forelli

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Georgios KakavasFysiotek Spine & Sports Lab, 17562 Athens, Greece.ORCID 0000-0002-9138-6994
Nikoloaos MalliaropoulosThessaloniki Sports Medicine Clinic, 54622 Thessaloniki, Greece.ORCID 0000-0002-5220-8992
Florian ForelliHaute-Ecole Arc Santé, HES-SO University of Applied Sciences and Arts Western Switzerland, 2800 Delémont, Switzerland.ORCID 0000-0001-8650-2746

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rehabilitation after anterior cruciate ligament reconstruction cannot be reduced to a linear, time-based sequence of protection, strength, and return to sport. Persistent asymmetries, quadriceps inhibition, and variable re-injury rates highlight that recovery is a complex adaptive process in which outcomes emerge from dynamic interactions between biological, neural, and psychological subsystems. Grounded in complexity science and chaos theory, this editorial reframes rehabilitation as the regulation of variability rather than its suppression. The Control-Chaos Continuum provides a practical structure to translate this concept into progressive exposure, where clinicians dose uncertainty as a therapeutic stimulus. Adaptive periodization replaces rigid stages with overlapping macro-blocks that respond to readiness, feedback, and context. Neuroplastic mechanisms and ecological dynamics justify the deliberate introduction of controlled "noise" to foster coordination, confidence, and resilience. Ultimately, the goal is not perfect control but stable performance under variability-the ability to function "at the edge of chaos." This conceptual perspective articulates a clinically actionable framework-linking the Control-Chaos Continuum with adaptive periodization-to guide non-linear decision-making and safe return-to-sport.

Indexed as

adaptive periodizationanterior cruciate ligament reconstructionchaoscomplexity

Identifiers

PMID41301184
PMCPMC12649574

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.