Evidence map›Paper›PMID 41301126›Full record

ReviewBioengineering (Basel, Switzerland)2025

The Effects of Virtual Reality Interventions on Motor Function Rehabilitation in Lower-Limb Amputees: A Systematic Review and Metanalysis.

Jade Paillet, Manuel Del Valle Rodríguez, Javier Herranz Vázquez, Francisco Javier Ruiz-Matas Contreras, Julia Raya-Benítez, María Granados Santiago, Marie Carmen Valenza

Abstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jade PailletInstitut de Formation en Masso-Kinésithérapie-Assas, Université Versailles-Saint Quentin en Yvelines, 78280 Paris, France.
Manuel Del Valle RodríguezDepartment of Physical Therapy, University of Granada, 18071 Granada, Spain.
Javier Herranz VázquezDepartment of Physical Therapy, University of Granada, 18071 Granada, Spain.
Francisco Javier Ruiz-Matas ContrerasDepartment of Physical Therapy, University of Granada, 18071 Granada, Spain.
Julia Raya-BenítezDepartment of Nursing, University of Granada, 18071 Granada, Spain.ORCID 0009-0007-6370-3482
María Granados SantiagoDepartment of Nursing, University of Granada, 18071 Granada, Spain.ORCID 0000-0002-3609-0509
Marie Carmen ValenzaDepartment of Physical Therapy, University of Granada, 18071 Granada, Spain.ORCID 0000-0003-2368-1307

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLower-limb amputation is a complex condition that profoundly affects motor function and patients' quality of life. Physical therapists are key in managing lower-limb amputees, and emerging technologies such as virtual reality offer promising tools to further enhance motor function. This review aims to assess the effectiveness of virtual reality-based rehabilitation in improving motor function in lower-limb amputees.

methodA systematic review was conducted using the PubMed, Scopus, and Web of Science databases, covering all studies published from their inception to July 2025. The study population consisted of adult lower-limb amputees receiving virtual reality-based rehabilitation, either alone or combined with other interventions. The search strategy included key terms such as "amputee," "limb loss," and "virtual reality," with no date restrictions.

resultsSix studies, all randomized controlled trials, were included and featured a variety of protocols. Meta-analysis showed no significant improvement in walking capacity in the experimental group when compared with controls (

conclusionsCurrent evidence suggests that virtual reality may be an effective approach to improving motor function in lower-limb amputees. However, the studies exhibit methodological limitations, highlighting the need for further research to standardize protocols and evaluate long-term benefits.

Indexed as

functional mobilitylower-limb amputationmotor functionvirtual reality

Identifiers

PMID41301126
PMCPMC12649739

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.