Evidence map›Paper›PMID 41301095›Full record

ReviewBioengineering (Basel, Switzerland)2025

Radiomics in Action: Multimodal Synergies for Imaging Biomarkers.

Everton Flaiban, Kaan Orhan, Bianca Costa Gonçalves, Sérgio Lúcio Pereira de Castro Lopes, Andre Luiz Ferreira Costa

Abstract readReview
In one paragraph

Review in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Quantitative Imaging of the Mandibular Condyle: Radiomics and Microarchitectural Biomarkers.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Everton FlaibanPostgraduate Program in Dentistry, Dentomaxillofacial Radiology and Imaging Laboratory, Cruzeiro do Sul University (UNICSUL), São Paulo 01506-000, Brazil.ORCID 0000-0002-0040-7834
Kaan OrhanDepartment of Dentomaxillofacial Radiology, Faculty of Dentistry, Ankara University, Ankara 06560, Turkey.ORCID 0000-0001-6768-0176
Bianca Costa GonçalvesDepartment of Diagnosis and Surgery, The Institute of Sciences and Technology of São Paulo State University (UNESP), São José dos Campos 12245-000, Brazil.ORCID 0009-0004-4206-0551
Sérgio Lúcio Pereira de Castro LopesDepartment of Diagnosis and Surgery, The Institute of Sciences and Technology of São Paulo State University (UNESP), São José dos Campos 12245-000, Brazil.ORCID 0000-0002-0882-5862
Andre Luiz Ferreira CostaPostgraduate Program in Dentistry, Dentomaxillofacial Radiology and Imaging Laboratory, Cruzeiro do Sul University (UNICSUL), São Paulo 01506-000, Brazil.ORCID 0000-0003-4856-5417

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Radiomics has recently begun as a transformative approach in medical imaging, shifting radiology from qualitative description to quantitative analysis. By extracting high-throughput features from CT (Computed Tomography), MRI (Magnetic Resonance Imaging), PET/CT (Positron Emission Tomography/Computed Tomography), and CBCT (Cone Beam Computed Tomography), radiomics enables the characterization of tissue heterogeneity and the development of imaging biomarkers with diagnostic, prognostic, and predictive values. This narrative review explores the historical evolution of radiomics and its methodological foundations, including acquisition, segmentation, feature extraction and modeling, and platforms supporting these workflows. Clinical applications are highlighted in oncology, cardiology, neurology, and musculoskeletal and dentomaxillofacial imaging. Despite being promising, radiomics faces challenges related to standardization, reproducibility, PACS/RIS (Picture Archiving and Communication System/Radiology Information System) integration and interpretability. Professional initiatives, such as the Image Biomarker Standardization Initiative (IBSI) and guidelines from radiological societies, are addressing these barriers by promoting harmonization and clinical translation. The ultimate vision is a radiomics-augmented radiology report in which validated biomarkers and predictive signatures complement conventional findings, thus enhancing objectivity, reproducibility, and advancing precision medicine.

Indexed as

artificial intelligencecone beam computed tomographyimaging biomarkersquantitative imagingradiomics

Identifiers

PMID41301095
PMCPMC12649724

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.