Evidence map›Paper›PMID 41300989›Full record

ReviewCancers2025

Current Clinical Paradigm and Therapeutic Advancements in Thymic Malignancies: A Narrative Review.

Douglas Dias E Silva, Beatriz Viesser Miyamura, Isa Mambetsariev, Jeremy Fricke, Javier Arias-Romero, Amit A Kulkarni, Ajaz Khan, Debora S Bruno, Jyoti Malhotra, Abigail Fong and 5 more

Abstract readReview
In one paragraph

Review in Cancers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Douglas Dias E SilvaDayan-Daycoval Family Hematology and Oncology Center, Hospital Israelita Albert Einstein, São Paulo 05652-900, SP, Brazil.
Beatriz Viesser MiyamuraDayan-Daycoval Family Hematology and Oncology Center, Hospital Israelita Albert Einstein, São Paulo 05652-900, SP, Brazil.
Isa MambetsarievDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.
Jeremy FrickeDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0003-4684-8114
Javier Arias-RomeroDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0009-0006-7629-7156
Amit A KulkarniDepartment of Medical Oncology and Therapeutics Research, City of Hope Phoenix, Goodyear, AZ 85338, USA.
Ajaz KhanDepartment of Medical Oncology and Therapeutics Research, City of Hope Chicago, Chicago, IL 60611, USA.
Debora S BrunoDepartment of Medical Oncology and Therapeutics Research, City of Hope Atlanta, Atlanta, GA 30265, USA.
Jyoti MalhotraDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0001-8586-0234
Abigail FongDepartment of Surgery, City of Hope, Duarte, CA 91010, USA.
Jae KimDepartment of Surgery, City of Hope, Duarte, CA 91010, USA.
Colton LadburyDepartment of Radiation Oncology, City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-2668-3415
Arya AminiDepartment of Radiation Oncology, City of Hope, Duarte, CA 91010, USA.
Gustavo SchvartsmanDayan-Daycoval Family Hematology and Oncology Center, Hospital Israelita Albert Einstein, São Paulo 05652-900, SP, Brazil.ORCID 0000-0001-6601-3726
Ravi SalgiaDepartment of Medical Oncology and Therapeutics Research, City of Hope National Medical Center, Duarte, CA 91010, USA.ORCID 0000-0001-9643-7626

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thymic epithelial tumors (TETs) are a diverse group of rare thymic tumors that arise from thymic epithelial cells. The rarity of these tumors has limited therapeutic advancements due to difficulty to enroll patients into Phase II and III clinical trials. Historically surgery, radiotherapy, and chemotherapy have been the mainstay therapeutic options for these patients with the development of new therapeutics hindered by the rarity, histological and molecular heterogeneity, and lack of actionable mutations. However, more recently, innovations in immunotherapy, next-generation tyrosine kinase inhibitors, and hyperthermic intrathoracic chemotherapy (HITHOC) have transformed the therapeutic landscape with more promising therapies currently under investigation. In this review we evaluate the histology and molecular subtypes of TETs, and discuss the therapeutic landscape including the current standard-of-care regimen as well as drugs that are currently in clinical trials.

Indexed as

immunotherapyprecision medicinetargeted therapythymic epithelial tumors

Identifiers

PMID41300989
PMCPMC12650598

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.