Evidence map›Paper›PMID 41300822›Full record

ArticleGenes2025

Pharmacogenetic Analysis of TPMT and NUDT15 in a European Pediatric Cohort with IBD and Autoimmune Diseases: Frequency Data and Clinical Relevance.

Anna Pau, Ilaria Galliano, Alice Ponte, Anna Clemente, Maddalena Dini, Cristina Calvi, Paola Montanari, Antonio Pizzol, Stefano Gambarino, Pier Luigi Calvo and 1 more

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Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anna PauDepartment of Public Health and Pediatrics, School of Medicine, University of Turin, 10126 Turin, Italy.ORCID 0009-0002-5430-6008
Ilaria GallianoDepartment of Public Health and Pediatrics, School of Medicine, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-1273-3178
Alice PonteUnit of Pediatric Gastroenterology, Department of Pediatric Pathology and Care, Regina Margherita Children's Hospital, 10126 Turin, Italy.ORCID 0009-0004-7875-4299
Anna ClementeDepartment of Public Health and Pediatrics, School of Medicine, University of Turin, 10126 Turin, Italy.
Maddalena DiniDepartment of Public Health and Pediatrics, School of Medicine, University of Turin, 10126 Turin, Italy.
Cristina CalviDepartment of Public Health and Pediatrics, School of Medicine, University of Turin, 10126 Turin, Italy.
Paola MontanariDepartment of Public Health and Pediatrics, School of Medicine, University of Turin, 10126 Turin, Italy.
Antonio PizzolUnit of Pediatric Gastroenterology, Department of Pediatric Pathology and Care, Regina Margherita Children's Hospital, 10126 Turin, Italy.
Stefano GambarinoDepartment of Public Health and Pediatrics, School of Medicine, University of Turin, 10126 Turin, Italy.
Pier Luigi CalvoUnit of Pediatric Gastroenterology, Department of Pediatric Pathology and Care, Regina Margherita Children's Hospital, 10126 Turin, Italy.
Massimiliano BergalloDepartment of Public Health and Pediatrics, School of Medicine, University of Turin, 10126 Turin, Italy.ORCID 0000-0002-9291-1332

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesThiopurines remain a cornerstone in the management of inflammatory bowel disease (IBD) and gastrointestinal immune diseases but are associated with significant interindividual variability in efficacy and toxicity, mainly influenced by polymorphisms in Thiopurine S-methyltransferase

methodsEighty-three pediatric patients with IBD and other autoimmune diseases were genotyped for clinically relevant

resultsAmong the cohort, six carried heterozygous

conclusionsOur results confirm the clinical relevance of

Indexed as

Autoimmune DiseasesInflammatory Bowel DiseasesMethyltransferasesPyrophosphatasesAdolescentAzathioprineChildChild, PreschoolClinical RelevanceCohort StudiesEuropeFemaleGene FrequencyGenotypeHumansMaleAzathioprineMethyltransferasesNudix HydrolasesNUDT15 protein, humanPyrophosphatasesthiopurine methyltransferaseTPMT protein, humanIBDNUDT15pediatricspharmacogeneticthiopurineTPMT

Identifiers

PMID41300822
PMCPMC12652446

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.