Evidence map›Paper›PMID 41300820›Full record

ArticleGenes2025

Dystrophin-Deficient Muscular Dystrophy in a Family of Shiba Inu Dogs with a Complex Deletion Encompassing

Laura Mcleay, Simone Hardinge, Katie M Minor, Steven G Friedenberg, Jonah N Cullen, Ling T Guo, G Diane Shelton

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laura McleaySmall Animal Specialist Hospital, North Ryde 2113, Australia.ORCID 0009-0004-6992-6634
Simone HardingeMelbourne Veterinary Specialist Centre, Glen Waverley, Victoria 3250, Australia.
Katie M MinorDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0000-0002-5472-5088
Steven G FriedenbergDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.ORCID 0000-0002-7510-2322
Jonah N CullenDepartment of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA.
Ling T GuoComparative Neuromuscular Laboratory, Department of Pathology, University of California San Diego, La Jolla, CA 92093, USA.
G Diane SheltonComparative Neuromuscular Laboratory, Department of Pathology, University of California San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-3332-1359

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTwo Shiba Inu littermates presented for investigation of marked and persistent elevation of creatine kinase activities. METHOD AND

resultsHistopathology of muscle biopsy samples revealed a dystrophic phenotype and immunostaining confirmed an absence of dystrophin protein in both cases. Whole genome sequencing of one affected dog revealed a complex deletion in the

conclusionThis study adds a new breed to the canine dystrophinopathy spectrum having a ~17 kb deletion that encompasses exon 5 of

Indexed as

Dog DiseasesDystrophinMuscular Dystrophy, AnimalMuscular Dystrophy, DuchenneSequence DeletionAnimalsDogsExonsFemaleMalePedigreeDystrophinacute deathcaninegenetic diseasemusclemyopathywhole genome sequencing

Identifiers

PMID41300820
PMCPMC12651955

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.