ArticleGenes2025
Reduced Sensorimotor, Working Memory, and Episodic Memory Abilities in Aging Female
Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
BACKGROUND/
objectivesFragile X-associated tremor/ataxia syndrome (FXTAS) is characterized by tremor, gait ataxia, and cerebellar white matter degeneration, along with possible cognitive and cerebral changes. Although diagnostic criteria were originally developed in males, emerging evidence suggests that FXTAS may present differently in females. The present study examined sensorimotor and memory features of aging in female premutation carriers with (FXTAS+) and without FXTAS (FXTAS-).
methodsWe studied 51 female premutation carriers (FXTAS+ = 16, FXTAS- = 35) and 24 age-matched female controls. Participants ranged in age from 47-80 years. All participants completed genetic testing, clinical evaluations, T2-weighted MRIs, and quantitative assessments of sensorimotor (precision grip force task) and memory (reading span; visual paired associates task) functions.
resultsDuring precision grip testing, FXTAS+ carriers showed higher sustained force regularity than FXTAS- carriers (
conclusionsTogether, these findings indicate that FXTAS+ females exhibit distinct motor and cognitive impairments, underscoring the value of quantitative behavioral measures for detecting and tracking neurodegenerative progression in female premutation carriers.
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