Evidence map›Paper›PMID 41300775›Full record

ArticleGenes2025

Endometrial Signatures of Subfertility in Beef Heifers Reveal Dysregulation of MAPK Signaling and Ciliary Function.

Nicholas C Kertz, Priyanka Banerjee, Paul W Dyce, Soren P Rodning, Wellison J S Diniz

Abstract read
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nicholas C KertzDepartment of Animal Sciences, Auburn University, Auburn, AL 36849, USA.ORCID 0009-0004-9248-0714
Priyanka BanerjeeDepartment of Animal Sciences, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0001-5054-3095
Paul W DyceDepartment of Animal Sciences, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0002-4574-3321
Soren P RodningDepartment of Animal Sciences, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0003-2128-9512
Wellison J S DinizDepartment of Animal Sciences, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0003-1082-5535

Funding

Foundation for Food and Agriculture Research FF-NIA19-0000000048U.S. Department of Agriculture Agreement No. 58-6010-1-005
6 · The paper itself

Abstract

backgroundReproductive efficiency is a significant hurdle to the sustainability of the beef cattle industry.

methodThis study employed transcriptomic profiling to investigate endometrial gene expression differences in heifers with divergent fertility outcomes. Caruncular endometrial samples from fertile (

resultsThe MAPK (Mitogen-activated protein kinase) and Rap1 (Ras-associated protein 1) signaling pathways and immune response regulation were identified among the over-represented pathways underlying the DEGs. Transcriptional regulators, such as

conclusionsThis study highlights novel molecular signatures in the uterine endometrium that may serve as predictive markers of fertility potential in beef heifers, providing a foundation for targeted strategies to improve reproductive performance in cattle.

Indexed as

CiliaEndometriumInfertility, FemaleMAP Kinase Signaling SystemAnimalsCattleFemaleGene Expression ProfilingGene Regulatory NetworksTranscriptomebeef heifersendometriumgene expressionMAPKsubfertilitytranscription factors

Identifiers

PMID41300775
PMCPMC12652950

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.