ArticleGenes2025
Gene Expression Dynamics Underlying Muscle Aging in the Hawk Moth
Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
BACKGROUND/
objectivesMuscle aging is a complex, dynamic process that impairs overall metabolism and physiological function. The molecular mechanisms underlying declines in muscle performance and metabolic efficiency remain poorly understood, largely due to the time and resource demands of traditional model organisms. The hawk moth
methodsIn this study, we performed high-resolution temporal analysis of muscle tissues from aging
resultsWe observed decreased expression of genes involved in fatty acid β-oxidation, ATP synthase subunits, superoxide dismutase, glutathione S-transferases, and heat shock proteins. In contrast, genes associated with proteolysis, catabolic processes, insulin signaling,
conclusionsThese changes suggest a shift toward increased proteolysis and protein catabolism with age. Our findings support the use of
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