Evidence map›Paper›PMID 41300741›Full record

ArticleGenes2025

Molecular Characterization of Hypothalamic-Pituitary-Ovarian Axis Regulation in the Manchurian Zokor (

Rile Nai, Xueru Li, Dan Shan, Saru Bao, Fei Wang, Yuerong Lin, Yan Zhang, Buqin Hu, Yuchun Xie, Duhu Man

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rile NaiCollege of Agriculture, Hulunbuir University, Hulunbuir 021008, China.
Xueru LiHebei Key Laboratory of Specialty Animal Germplasm Resources Exploration and Innovation, College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066004, China.
Dan ShanCollege of Agriculture, Hulunbuir University, Hulunbuir 021008, China.
Saru BaoHulunbuir Academy of Inland Lakes in Northern Cold & Arid Areas, Hulunbuir 021008, China.
Fei WangCollege of Agriculture, Hulunbuir University, Hulunbuir 021008, China.
Yuerong LinCollege of Agriculture, Hulunbuir University, Hulunbuir 021008, China.
Yan ZhangCollege of Agriculture, Hulunbuir University, Hulunbuir 021008, China.
Buqin HuCollege of Agriculture, Hulunbuir University, Hulunbuir 021008, China.
Yuchun XieHebei Key Laboratory of Specialty Animal Germplasm Resources Exploration and Innovation, College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066004, China.
Duhu ManCollege of Agriculture, Hulunbuir University, Hulunbuir 021008, China.

Funding

the Doctoral Fund Project of Hulunbuir College 2020BS12the Doctoral Fund Project of Hulunbuir College 2023BSJJ08the Hulunbuir College General Natural Science Project 2020ZKYB14the Tast Book of Special Project for Basic Research Business Expenses of Hebei Normal University of Science and Technology 2023JK06
6 · The paper itself

Abstract

BACKGROUND/

objectivesSeasonal reproduction in mammals is primarily regulated by the hypothalamic-pituitary-ovarian (HPO) axis, yet its molecular mechanisms in subterranean rodents living in light-restricted environments remain poorly understood. This study aimed to characterize the transcriptional regulation of the HPO axis during seasonal estrus in the Manchurian zokor (

methodsHypothalamic, pituitary, and ovarian tissues were collected from female zokors during estrus and anestrus (

resultsA total of 513, 292, and 138 DEGs were identified in the hypothalamus, pituitary, and ovary, respectively. GO analysis highlighted enrichment in G-protein-coupled receptor signaling, oxidation-reduction processes, and calcium ion binding. KEGG pathway analysis revealed significant enrichment of the neuroactive ligand-receptor interaction pathway across all three tissues. Key candidate genes included

conclusionsThis study provides the first comprehensive transcriptomic profile of the HPO axis in Manchurian zokors during seasonal estrus. The neuroactive ligand-receptor interaction pathway appears central to reproductive regulation, and several tissue-specific genes were identified as potential regulators of seasonal breeding. These findings enhance our understanding of reproductive adaptation in subterranean mammals and offer a foundation for further functional studies.

Indexed as

EstrusHypothalamo-Hypophyseal SystemOvaryRodentiaAnimalsFemaleGene Expression ProfilingGene Expression RegulationHypothalamusPituitary GlandSeasonsTranscriptomeanestrusestrusHPO axisManchurian zokorseasonal reproductiontranscriptome

Identifiers

PMID41300741
PMCPMC12652709

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.