ReviewChildren (Basel, Switzerland)2025
Acid-Base Status and Cerebral Oxygenation in Neonates: A Systematic Qualitative Review of the Literature.
Review in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
Funding
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Abstract
introductionBlood gas analysis is utilized to assess parameters of oxygenation and ventilation, including acid-base status [pH value, base excess (BE) or base deficit (BD), and bicarbonate (HCO
methodsA systematic search of PubMed and Ovid Embase was performed, focusing on cerebral oxygenation, neonates, and acid-base status. Risk of bias was assessed using the ''Risk of Bias for Non-randomized Studies of Exposures'' (ROBINS-E) instrument.
resultsFifty studies that measured parameters of the acid-base status and cerebral tissue oxygenation in the neonatal period were identified. Seven studies demonstrated a correlation between pH and cerebral tissue oxygenation, while eleven studies found no such correlation. Five studies demonstrated a correlation between the BE/BD and cerebral tissue oxygenation, while six studies found no such correlation. Three studies demonstrated a correlation between HCO DISCUSSION: Associations between acid-base status parameters and cerebral tissue oxygenation remain controversial. However, studies with the lowest risk of bias mainly demonstrated no significant correlation between any of the acid-base status parameters and cerebral tissue oxygenation.
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