Evidence map›Paper›PMID 41300641›Full record

ArticleChildren (Basel, Switzerland)2025

Significant Response to Denosumab Yet with Severe Rebound Hypercalcemia in a 9-Year-Old Boy with Aneurysmal Bone Cyst: A Case Report.

Laurence Allain, Sarah Elbaz, Sayanthen Sathyakumar, William Le Gallou, Christina Coleman, Hallie Coltin, Dardye Eugène, Abha Gupta, Sebastiano A G Lava, Samuele Renzi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Laurence AllainFaculty of Medicine, Laval University, Quebec City, QC G1V 0A6, Canada.
Sarah ElbazFaculty of Medicine, Laval University, Quebec City, QC G1V 0A6, Canada.
Sayanthen SathyakumarFaculty of Medicine, Laval University, Quebec City, QC G1V 0A6, Canada.
William Le GallouDivision of Pediatric Hematology Oncology, CHUL-Laval, Quebec City, QC G1V 0A6, Canada.ORCID 0009-0005-1270-3701
Christina ColemanMontreal Children's Hospital, Montréal, QC H4A 3H9, Canada.
Hallie ColtinDepartment of Pediatric Hematology/Oncology, CHU Sainte Justine, Université de Montréal, Montréal, QC H3C 3A7, Canada.
Dardye EugèneDivision of Pediatric Endocrinology, CHUL-Laval, Quebec City, QC G1V 0A6, Canada.ORCID 0009-0009-8270-0417
Abha GuptaPrincess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1X6, Canada.ORCID 0000-0002-0825-5070
Sebastiano A G LavaPaediatric Cardiology Unit, Department of Pediatrics, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Rue du Bugnon 50, 1011 Lausanne, Switzerland.ORCID 0000-0002-8391-5462
Samuele RenziFaculty of Medicine, Laval University, Quebec City, QC G1V 0A6, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 9-year-old boy presented with edema of the left cheek. He was diagnosed with a large aneurysmal bone cyst of the mandibular bone. Off-label treatment with denosumab for 17 months resulted in a significant reduction in the lesion. Five months after discontinuing denosumab, the patient developed severe rebound hypercalcemia and acute kidney injury, which resolved with corticosteroids. Two years after treatment discontinuation, the lesion continues to decrease in size. This case highlights the efficacy of denosumab as an off-label treatment for aneurysmal bone cysts, though it can be associated with hypercalcemia and acute kidney injury. We conclude that the use of denosumab should be considered on a case-by-case basis, with regular monitoring for side effects.

Indexed as

acute kidney injuryaneurysmal bone cystbonesdenosumabhypercalcemiarare pediatric tumorstargeted therapytoxicitytumor

Identifiers

PMID41300641
PMCPMC12651796

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.