ArticleChildren (Basel, Switzerland)2025
Usefulness of Non-High-Density Lipoprotein Cholesterol for Screening Dyslipidemia in Children and Adolescents with Overweight or Obesity: A Single-Center Retrospective Study.
Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BACKGROUND/
objectivesNon-high-density lipoprotein (non-HDL) cholesterol provides a practical alternative for assessing dyslipidemia, with the advantage of not requiring fasting. The aim of this study was to evaluate the utility of non-HDL cholesterol measured in random (non-fasting) samples for screening dyslipidemia in children and adolescents with overweight or obesity.
methodsWe retrospectively analyzed 751 children and adolescents (268 boys and 483 girls) aged 2 to 19 years with overweight or obesity. They underwent lipid profile evaluation without fasting. Dyslipidemia was defined as the presence of one or more of the following: total cholesterol ≥ 200 mg/dL, triglycerides ≥ 100 mg/dL (ages 0-9) or ≥130 mg/dL (ages 10-19), low-density lipoprotein (LDL) cholesterol ≥ 130 mg/dL, and HDL cholesterol < 40 mg/dL. A cutoff value of ≥145 mg/dL was used for non-HDL cholesterol. The sensitivity and specificity of non-HDL cholesterol were compared with those of fasting-state data from the Korean National Health and Nutrition Examination Survey.
resultsDyslipidemia was identified in 52.6% of children and adolescents with overweight or obesity. Non-HDL cholesterol ≥ 145 mg/dL was observed in 18.7% of boys and 17.0% of girls, and dyslipidemia was observed in 94.0% and 85.4% of boys and girls with high non-HDL cholesterol, respectively. Non-HDL cholesterol demonstrated excellent performance in detecting elevated measured LDL cholesterol, with a sensitivity and specificity of 100% and 92.0%, respectively, for boys and 97.8% and 91.3%, respectively, for girls. When stratified by age, non-HDL cholesterol showed sensitivity comparable to or higher than that of total cholesterol for both boys and girls. The sensitivity of non-HDL cholesterol in random samples was significantly higher than that of non-HDL cholesterol in fasting-state samples from boys (100% vs. 94.3%,
conclusionsNon-HDL cholesterol measurement may be a reliable and practical tool for dyslipidemia screening in children and adolescents with overweight or obesity. Its applicability in non-fasting conditions makes it a convenient tool for routine clinical use.
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