Evidence map›Paper›PMID 41300594›Full record

ReviewChildren (Basel, Switzerland)2025

Pathogen Profiles and Antimicrobial Resistance Patterns of Neonatal Sepsis in the Gulf Cooperation Council: A Systematic Review.

Razique Anwer, Hassan Al-Shehri, Musab Alsulami, Ziyad Alsulami, Faisal Alzkari, Nawaf Alshaalan, Nawaf Almutairi, Abdullah Saleh Albalawi, Khalid Alshammari, Abdulelah F Alshehri and 4 more

Abstract readReview
In one paragraph

Review in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Razique AnwerDepartment of Pathology, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317-4233, Saudi Arabia.ORCID 0000-0002-9223-1951
Hassan Al-ShehriDepartment of Pediatrics, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317-4233, Saudi Arabia.ORCID 0000-0003-2972-8276
Musab AlsulamiCollege of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317-4233, Saudi Arabia.
Ziyad AlsulamiCollege of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317-4233, Saudi Arabia.
Faisal AlzkariCollege of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317-4233, Saudi Arabia.
Nawaf AlshaalanCollege of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317-4233, Saudi Arabia.
Nawaf AlmutairiCollege of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317-4233, Saudi Arabia.
Abdullah Saleh AlbalawiCollege of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317-4233, Saudi Arabia.
Khalid AlshammariCollege of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317-4233, Saudi Arabia.
Abdulelah F AlshehriCollege of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317-4233, Saudi Arabia.
Nawaf AlzahraniCollege of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317-4233, Saudi Arabia.
Ibrahim A AlamerCollege of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317-4233, Saudi Arabia.ORCID 0009-0009-1131-309X
Albaraa AlotaibiCollege of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317-4233, Saudi Arabia.ORCID 0009-0009-5814-0835
Meshal AlzakariCollege of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317-4233, Saudi Arabia.ORCID 0000-0002-4530-4708

Funding

Deanship of Scientific Research, Imam Mohammad Ibn Saud Islamic University (IMSIU) IMSIU-DDRSP2501
6 · The paper itself

Abstract

backgroundNeonatal sepsis (NS) is a life-threatening condition in newborns, which is an infectious process with a systemic inflammatory reaction to bacterial, viral, or fungal infection acquired in the first 28 days of life.

methodsThis study examines the major pathogens causing neonatal sepsis in the Gulf Cooperation Council (GCC) and their resistance patterns to antimicrobial agents. We utilized the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to develop this systematic review to follow a systematic and transparent process. The comprehensive literature review was done in several national and global databases, which include PubMed, Scopus, Google Scholar, Embase, and Cochrane Library. The key words inserted in the search strategy were "neonatal sepsis," "late-onset sepsis," "early-onset sepsis," and "Gulf Cooperation Council (GCC)," and the keywords of antimicrobial resistance and pathogens were used: "antimicrobial drug resistance" and "pathogens." Only articles published from January 1983 to January 2025 were included for screening.

resultsThe final count of the articles that fit the inclusion criteria is 54, and 5177 neonatal sepsis cases' data have been identified. The most common pathogens were coagulase-negative staphylococci (CoNS) and

conclusionsThe bacterial isolates had a diversity of antimicrobial resistance, stressing the necessity of continuous hospital surveillance. Sophisticated diagnostic methods and well-designed research are necessary, especially in areas characterized by high rates of neonatal mortality, to determine the prevalence of neonatal sepsis, risk factors, and clinical outcomes.

Indexed as

antibiotic resistanceGulf Cooperation Council (GCC)neonatal sepsispathogens

Identifiers

PMID41300594
PMCPMC12650816

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.