ReviewChildren (Basel, Switzerland)2025
Furosemide-Induced Nephrocalcinosis in Premature Neonates: A Critical Review of Observational Data.
Review in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- From mechanisms to clinical practice: a review of diuretic therapy in pediatric nephrology.Pediatric nephrology (Berlin, Germany) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesFurosemide is frequently used in preterm neonates for respiratory and fluid management but has been linked to nephrocalcinosis (NC), a renal complication with unclear long-term impact. Clarifying this association is crucial for safe diuretic use.
methodsA focused literature review included observational studies published between 1982 and 2025 reporting NC incidence by renal ultrasound in preterm infants receiving furosemide. Data on sample size, gestational age, birth weight, NC prevalence, and furosemide dosing/duration were extracted. Results were synthesized descriptively.
resultsTwenty-two studies with 1489 infants were included. NC prevalence ranged 6-83%, higher in infants <32 weeks' gestation or <1500 g. Across studies, incidence clustered at 17-41% between 4 weeks and term-equivalent age. Cumulative furosemide doses were generally three- to fourfold higher in NC groups (10-19 mg/kg cumulative vs. ≤5 mg/kg cumulative,
conclusionsEvidence supports a dose-related association between furosemide and NC in preterm infants. When administered cautiously within defined limits, risk may be mitigated. Careful dosing, monitoring, and further studies are essential for safe use.
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Registered trials
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