Evidence map›Paper›PMID 41300481›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Cepharanthine Induces Oxidative Stress and Apoptosis in Cervical Cancer via the Nrf2/Keap1 Pathway.

Ya-Hui Chen, Jyun-Xue Wu, Shun-Fa Yang, Tze-Ho Chen, Yun-Chia Wu, Tzu-Chi Lin, Yi-Hsuan Hsiao

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Oxidative stress in neurodegeneration: from a simple insult to a dynamic regulator.Redox report : communications in free radical research · 2026
    Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ya-Hui ChenWomen's Health Research Laboratory, Changhua Christian Hospital, Changhua 50006, Taiwan.
Jyun-Xue WuWomen's Health Research Laboratory, Changhua Christian Hospital, Changhua 50006, Taiwan.
Shun-Fa YangInstitute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan.ORCID 0000-0002-0365-7927
Tze-Ho ChenDepartment of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua 50006, Taiwan.
Yun-Chia WuDepartment of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua 50006, Taiwan.
Tzu-Chi LinDepartment of Obstetrics and Gynecology, Changhua Christian Hospital, Changhua 50006, Taiwan.ORCID 0009-0006-6002-2887
Yi-Hsuan HsiaoWomen's Health Research Laboratory, Changhua Christian Hospital, Changhua 50006, Taiwan.

Funding

Changhua Christian Hospital 112-CCH-IRP-104Changhua Christian Hospital 113-CCH-IRP-049Changhua Christian Hospital 113-CCH-IRP-075
6 · The paper itself

Abstract

Cervical cancer ranks as a primary contributor to cancer-related deaths in women globally and is the fourth most prevalent malignant neoplasm. Cepharanthine, a naturally occurring biscoclaurine alkaloid extracted from

Indexed as

anticancer activityapoptosiscepharanthinecervical cancerNrf2/Keap1 pathwayROS

Identifiers

PMID41300481
PMCPMC12649129

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.