Evidence map›Paper›PMID 41300428›Full record

ReviewAntioxidants (Basel, Switzerland)2025

Calafate (

Jaime Ortiz-Viedma, Claudia Vergara, Tamar Toledo, Liliana Zura-Bravo, Marcos Flores, Constanza Barrera, Roberto Lemus-Mondaca

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jaime Ortiz-ViedmaDepartment of Food Science and Chemical Technology, Faculty of Chemical Sciences and Pharmaceutical, Universidad de Chile, St. Dr. Carlos Lorca 964, Independencia, Santiago 8330601, Chile.ORCID 0000-0002-4176-9065
Claudia VergaraDepartment of Basic Sciences, Faculty of Sciences, Santo Tomas University, Avenida Carlos Schorr 255, Talca 3460000, Chile.ORCID 0000-0001-5282-6056
Tamar ToledoDepartment of Analytical Chemistry, Nutrition and Food Science, Food Technology Division, School of Veterinary Sciences, University of Santiago de Compostela, 27002 Lugo, Spain.
Liliana Zura-BravoFood Science Lab, Faculty of Medicine and Health Sciences, Universidad Central de Chile, Santiago 8330546, Chile.ORCID 0000-0003-1403-5872
Marcos FloresDepartment of Horticulture, Faculty of Agricultural Sciences, University of Talca, Av. Lircay s/n, Talca 3460000, Chile.ORCID 0000-0002-2085-5706
Constanza BarreraDepartment of Food Science and Chemical Technology, Faculty of Chemical Sciences and Pharmaceutical, Universidad de Chile, St. Dr. Carlos Lorca 964, Independencia, Santiago 8330601, Chile.
Roberto Lemus-MondacaDepartment of Food Science and Chemical Technology, Faculty of Chemical Sciences and Pharmaceutical, Universidad de Chile, St. Dr. Carlos Lorca 964, Independencia, Santiago 8330601, Chile.ORCID 0000-0002-1252-2573

Funding

ANID-Fondecyt 1231528ANID-Fondecyt 1241011
6 · The paper itself

Abstract

Calafate berry, an ancient perennial shrub of South America (Chile and Argentina), produces a high antioxidant capacity berry with a high polyphenol (1344.2-6553 mg GAE/100 g d.w.) and anthocyanin (26.5-80 mg C-3-G/100 g d.w.) content. The beneficial effects of calafate berries on human health are related to the anti-inflammatory, hypoglycemic, anticancer, and antioxidant properties that the berries possess, which have been confirmed through evidence to date, primarily from in vitro, ex vivo, and animal studies. Several investigations have shown a relationship between the consumption of calafate and a reduction in the risk of contracting cardiovascular diseases (CVD). This was evident in changes in plasma level biomarkers related to CVD, such as thrombomodulin (-24%), adiponectin (+68%), sE-selectin (-34%), sICAM-1 (-24%) and proMMP-9 (-31%), and changes in the production of OH radicals in plasma (-17%) after calafate intake. Calafate may have an antithrombotic role that supports cardiovascular health by lowering the Atherogenic and Cardiovascular Risk Indices. Various authors indicate delphinidin-3-glucoside (384-386 mg/100 g) as the primary bioactive compound responsible for the beneficial properties of Calafate. Although some studies report calafate's health benefits, scientific evidence, especially in humans, remains limited. Meanwhile, Chile is working to domesticate and cultivate calafate, aiming to turn it from a wild native berry into a sustainable crop for use in the antioxidants and nutraceuticals industry. The lack of human clinical trials emphasizes the need for future research to validate calafate's health benefits berry.

Indexed as

anthocyaninsantioxidantscalafatehealthyproduction

Identifiers

PMID41300428
PMCPMC12649473

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.