LIMK1 Deficiency Disrupts Hippocampal-Cortical Memory Consolidation and Attenuates Trauma-Induced PTSD-like Behavior.

Xiangyu Yang, Zhengping Wu, Ziying Wang, Lihui Wang, Shuting Xia, Weidong Li, Guiqin He

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Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Xiangyu YangKey Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Bio-X Institutes, Shanghai Jiao Tong University, Shanghai 200030, China.ORCID 0000-0003-1081-3657

Zhengping WuSchool of Electronic Science and Engineering, Nanjing University, Nanjing 210000, China.ORCID 0000-0001-7696-8024

Ziying WangKey Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Bio-X Institutes, Shanghai Jiao Tong University, Shanghai 200030, China.

Lihui WangShanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.

Shuting XiaCancer Institute, Suzhou Medical College, Soochow University, Suzhou 215021, China.ORCID 0000-0003-2577-4339

Weidong LiKey Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Bio-X Institutes, Shanghai Jiao Tong University, Shanghai 200030, China.ORCID 0000-0001-5384-4838

Guiqin HeShanghai Key Laboratory of Psychotic Disorders, Brain Health Institute, National Center for Mental Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.

Funding

National Natural Science Foundation of China 82001372, 82201566Natural Science Foundation of Chongqing cstc2021jcyj-msxmX0130Open Projects of the Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders at Shanghai Jiao Tong University 2022GDND03Shanghai Jiao Tong University Grants YG2022QN108Shanghai Mental Health Center Grants 2021-YJ01, 2021-QH-03Shanghai Sailing Program 22YF1439300

6 · The paper itself

Abstract

Memory consolidation is the process by which newly acquired experiences are stabilized into long-term memory, involving coordinated cellular and network-level activity across brain regions such as the hippocampus and prefrontal cortex. Dysregulation of this process has been implicated in psychiatric disorders including post-traumatic stress disorder (PTSD), which is characterized by the over-consolidation of traumatic memories. LIM kinase 1 (LIMK1), a key regulator of synaptic plasticity, is believed to play an important role in memory consolidation across hippocampal-cortical circuits. In this study, we investigated the function of LIMK1 using

Indexed as

hippocampal–cortical circuitLIM-kinasememory consolidationPTSD-like behaviorunderwater trauma

Identifiers

PMID41300350

DOI10.3390/biology14111560

PMCPMC12650199

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