ArticleBrain sciences2025
Type 2 Diabetes Mellitus Exacerbates Brain Injury After
Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical and experimental evidence suggests comorbidity between diabetes mellitus (DM) and epilepsy, including a higher incidence of
methodsTo induce T2DM, postnatal day (P) 3 rats were injected with streptozocin (STZ, 100 mg/kg, s.c.; n = 18); control rats received an equal volume of citrate buffer (pH 4.5) used as vehicle (n = 16). Glycemia was monitored at P30, P40, P60, and P90 in both experimental groups. Subsequently, rats were injected intraperitoneally with lithium chloride (LiCl, 3 mEq/kg, i.p.), and 18 h later, at P90, SE was induced by pilocarpine hydrochloride (30 mg/kg, s.c.). Matched control rats were injected with LiCl and physiological saline solution. The severity of SE, the neurodegeneration, cell and tissue loss, and microglia and glial responses were evaluated in the hippocampus, amygdala, thalamus, the piriform cortex.
resultsHyperglycemia was evident at P90 in STZ rats compared with vehicle (
conclusionsOur findings suggest that T2DM is associated with greater seizure severity and increased brain injury following SE.
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