Evidence map›Paper›PMID 41300159›Full record

ArticleBrain sciences2025

Efficiency of a Protective Mode of Mechanical Ventilation in Patients with Severe Traumatic Brain Injury Complicated by Acute Respiratory Distress Syndrome.

Marta Rachel, Svitlana Yaroslavska, Konstiantyn Krenov, Maryna Mamonowa, Andriy Dobrorodniy, Oleksandr Oliynyk

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Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marta RachelDepartment of Allergology and Cystic Fibrosis, Rzeszow University, 35-315 Rzeszów, Poland.
Svitlana YaroslavskaDepartment of Anesthesiology and Intensive Care, Bogomolets National Medical University, 01601 Kyiv, Ukraine.
Konstiantyn KrenovDepartment of Surgery with a Course in the Basics of Dentistry, Faculty of Postgraduate Education, Vinnytsia National Medical University Named After M. I. Pirogov, Pilotna St. 1, 29000 Khmelnytski, Ukraine.
Maryna MamonowaDepartment of Anesthesiology and Intensive Care, Bogomolets National Medical University, 01601 Kyiv, Ukraine.
Andriy DobrorodniyDepartment of Anesthesiology and Intensive Care, Ternopil National Medical University, 46000 Ternopil, Ukraine.
Oleksandr OliynykDepartment of Anesthesiology and Intensive Care, Bogomolets National Medical University, 01601 Kyiv, Ukraine.ORCID 0000-0003-2886-7741

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesTreatment of severe traumatic brain injury (TBI) remains a major challenge in neurocritical care. The functional state of the brain largely depends on the applied ventilation strategy. Many patients develop acute respiratory distress syndrome (ARDS), for which lung-protective ventilation is recommended. However, its effect on outcomes in severe TBI remains unclear. This study aimed to assess whether a lung-protective ventilation strategy improves short-term outcomes in patients with severe TBI complicated by ARDS.

methodsThis multicenter retrospective study included patients with severe TBI and ARDS treated in three Ukrainian tertiary hospitals. Lung-protective ventilation was defined as the use of a low tidal volume and moderate positive end-expiratory pressure (PEEP). The primary endpoint was 28-day mortality; secondary endpoints included the Glasgow Coma Scale (GCS) score and intracranial pressure (ICP) on day 28. Univariate and multivariate logistic regression analyses identified factors associated with mortality.

resultsMortality did not depend on arterial PaO

conclusionsLung-protective ventilation is safe and effective in severe TBI with ARDS, significantly improving short-term survival without compromising cerebral outcomes.

Indexed as

acute respiratory distress syndromeprotective lung ventilationsevere traumatic brain injury

Identifiers

PMID41300159
PMCPMC12650321

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.