Evidence map›Paper›PMID 41300032›Full record

ArticleFoods (Basel, Switzerland)2025

Machine Learning-Enabled Rapid Assessment of Plant-Based Protein Digestibility Through Physicochemical Profiles.

Meichen Liu, Ruoyan Zhang, Hao Yin, Yu Zhong, Yapeng Fang, Cuixia Sun, Yun Deng

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meichen LiuDepartment of Food Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Ruoyan ZhangDepartment of Food Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Hao YinDepartment of Food Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Yu ZhongDepartment of Food Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Yapeng FangDepartment of Food Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Cuixia SunDepartment of Food Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
Yun DengDepartment of Food Science and Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.ORCID 0000-0003-0647-3151

Funding

National Key R&D Program of China 2023YFF1104302
6 · The paper itself

Abstract

Plant-based proteins offer sustainable alternatives to animal sources, yet their lower digestibility remains a critical barrier to widespread applications. Current digestibility assessment methods require days of analysis and gram-scale samples, creating significant bottlenecks in protein optimization workflows. This study developed an ensembled deep learning framework that transforms digestibility prediction from a resource-intensive process to a rapid, minimal-sample assessment. By systematically characterizing 23 diverse plant protein isolates across multiple physicochemical dimensions, we trained a feedforward neural network based on augmented data. Our model identified α-helix content, random coil content, and solubility as key digestibility indicators. This insight enabled the construction of a streamlined three-feature model that reduced assessment time by 80% while requiring only one-hundredth of standard sample amounts. When validated against independent published datasets, the model achieved rational prediction accuracy, with an R

Indexed as

artificial intelligencedigestibilityfeedforward neural networkphysicochemical indicatorsplant-based protein

Identifiers

PMID41300032
PMCPMC12651773

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.