Evidence map›Paper›PMID 41300006›Full record

ArticleFoods (Basel, Switzerland)2025

Screening and Identification of Antioxidant Peptides from Sea Cucumber Gonad Proteins and Their Activation of Superoxide Dismutase.

Zhiqin Zhang, Jingxuan Wang, Yongke Deng, Yugui Wang, Peipei Dou, Hongbing Fan, Xiangquan Zeng, Xinguang Fan, Lili Zhang, Haimei Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhiqin ZhangCollege of Food Engineering, Ludong University, Yantai 264025, China.
Jingxuan WangCollege of Food Engineering, Ludong University, Yantai 264025, China.
Yongke DengCollege of Food Engineering, Ludong University, Yantai 264025, China.
Yugui WangDepartment of Animal and Food Sciences, University of Kentucky, Lexington, KY 40546, USA.
Peipei DouDepartment of Animal and Food Sciences, University of Kentucky, Lexington, KY 40546, USA.
Hongbing FanDepartment of Animal and Food Sciences, University of Kentucky, Lexington, KY 40546, USA.ORCID 0000-0003-1049-6815
Xiangquan ZengDepartment of Food Science, College of Agriculture, Purdue University, West Lafayette, IN 47907, USA.
Xinguang FanCollege of Food Engineering, Ludong University, Yantai 264025, China.
Lili ZhangCollege of Food Engineering, Ludong University, Yantai 264025, China.
Haimei LiuCollege of Food Engineering, Ludong University, Yantai 264025, China.
Qin ZhaoCollege of Food Engineering, Ludong University, Yantai 264025, China.

Funding

The Innovation Project for graduate students of Ludong University Grant No. IPGS2025-081The Major Science and Technology Innovation Project of Yantai City, Shandong Province Grant No. 2023YT06000829The Yantai Science and Technology Program Grant No. 2022XDRH012
6 · The paper itself

Abstract

The gonad is one of the major byproducts of sea cucumber. Four novel antioxidant peptides (NPWGQ, PGHPF, VPYPR and ATGPQGPAGQRGPAGPTGPTGPAG) were isolated and identified from sea cucumber gonad proteins through enzymatic hydrolysis and antioxidant activity-guided fractionation, bioinformatics approaches and in silico screening. These peptides demonstrated great free radical (2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS))-scavenging activity and notable superoxide dismutase (SOD)-activation capacity. Molecular docking and molecular dynamics simulation data suggested that these peptides could form strong binding with SOD through hydrogen bonding, electrostatic interactions, and hydrophobic interactions. Among these peptides, NPWGQ displayed the most potent antioxidant and SOD-activating effects. Through searching known databases, these peptides did not show potential toxicity and are generally considered safe. The present study provides crucial theoretical support for comprehensively utilizing sea cucumber (

Indexed as

antioxidant peptidemolecular dockingmolecular dynamics simulationsea cucumber gonadvirtual screening

Identifiers

PMID41300006
PMCPMC12651066

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.