ArticleBrain and behavior2025
Motion-Style Scalp Acupuncture Ameliorates Post-Stroke Muscle Spasticity Through Cerebral Blood Flow Augmentation and 5-HT
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Pulsed Radiofrequency for Post-Stroke Complications: From Neuromodulation to Functional Recovery.Current neurology and neuroscience reports · 2026Review
- Motion-Style Scalp Acupuncture Ameliorates Post-Stroke Muscle Spasticity Through Cerebral Blood Flow Augmentation and 5-HTBrain and behavior · 2025Article
- Efficacy and safety of acupuncture for post-stroke spasticity: a study protocol for a randomized controlled trial.Frontiers in neurologyArticle
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Authors and funding
9 authors.
Funding
Abstract
backgroundMuscle spasticity, a prevalent and debilitating motor impairment after stroke, severely compromises patients' functional recovery and quality of life. Motion-style scalp acupuncture (MSSA), a novel integrative therapy combining scalp acupuncture (SA) with targeted exercise training, has emerged as a promising strategy for post-stroke spasticity (PSS). This study investigated the mechanisms underlying MSSA's therapeutic effects, focusing on 5-HT
methodsUsing a rat model of permanent middle cerebral artery (MCA) occlusion, we evaluated MSSA's effects through behavioral assessments (Zea Longa, modified Ashworth scale (MAS), screen test), cerebral blood flow (laser speckle imaging), and infarct area analysis (TTC staining). Spinal reflex excitability was quantified via H-reflex electrophysiological recordings, while molecular mechanisms were examined using Western blot, RT-qPCR, and double immunofluorescence labeling.
resultsOur results demonstrated that MSSA significantly improved neurological function, reduced muscle tone, and attenuated spinal hyperreflexia. These improvements were associated with enhanced cerebral blood flow and reduced infarct areas. Furthermore, MSSA significantly upregulated the expression of 5-HT
conclusionThese findings demonstrate that MSSA ameliorates PSS through dual mechanisms: improving cerebral blood flow to the ischemic penumbra and restoring spinal inhibitory control via 5-HT
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