ArticleJournal of dental research2026
CD69 Regulates Gingival Inflammation and Microbiome in Periodontitis.
F M Saavedra, L Fischer, P D Bittner-Eddy, K F Johnstone, J M Stolley, D W Williams, M C Herzberg, M Costalonga
Abstract read
In one paragraphArticle in Journal of dental research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
F M SaavedraDepartment of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA.ORCID 0000-0001-8623-8543 L FischerDepartment of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA.
P D Bittner-EddyDepartment of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA.
K F JohnstoneDepartment of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA.
J M StolleyDepartment of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH, USA.
D W WilliamsDepartment of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA.
M C HerzbergDepartment of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA.
M CostalongaDepartment of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA.
Funding
Calprotectin-mediated CD69 signaling in periodontitisR01DE030095 · NIDCR · UNIVERSITY OF MINNESOTA · PI COSTALONGA, MASSIMO · 2021 to 2025
$2.1MMinnesota Craniofacial Research Training ProgramR90DE023058 · NIDCR · UNIVERSITY OF MINNESOTA · PI MANSKY, KIM CARPENTER · 2012 to 2022
$1.2MT cell response in Aggregatibacter actinomycetemcomitans-associated periodontal diseaseR00DE032747 · NIDCR · UNIVERSITY OF MINNESOTA · PI Drake Winslow Williams · 2025 to 2026
$494kCalprotectin and CD69 affect regulatory T cell responses in periodontal diseaseR21DE029601 · NIDCR · UNIVERSITY OF MINNESOTA · PI COSTALONGA, MASSIMO · 2021 to 2022
$426kNIDCR NIH HHS R00 DE032747NIDCR NIH HHS R01 DE030095NIDCR NIH HHS R21 DE029601NIDCR NIH HHS R90 DE023058
6 · The paper itselfAbstract
Dysbiotic subgingival biofilms initiate periodontitis, while the consequential destruction of periodontal tissues results from a dysregulated local immune response. Interstitial CD4
Indexed as
Antigens, CDAntigens, Differentiation, T-LymphocyteGingivitisLectins, C-TypeMicrobiotaPeriodontitisAlveolar Bone LossAnimalsCD4-Positive T-LymphocytesCD69 AntigensGingivaInterleukin-17MiceMice, Inbred C57BLMice, KnockoutAntigens, CDAntigens, Differentiation, T-LymphocyteCD69 AntigensInterleukin-17Lectins, C-Typecytokineshost–pathogen interactionsinflammationmicrobiomemucosal immunityperiodontal tissues/periodontium
Identifiers
PMID41299866
PMCPMC12912275
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