Evidence map›Paper›PMID 41299853›Full record

ArticleEuropean journal of oral sciences2026

Cytotoxicity of ammonia- and water-based silver fluoride treatments.

Merve Uctasli, Roda Seseogullari-Dirihan, Mustafa Murat Mutluay, Arzu Tezvergil-Mutluay

Abstract read
In one paragraph

Article in European journal of oral sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Merve UctasliDepartment of Restorative Dentistry and Cariology, Adhesive Dentistry Research Group, Institute of Dentistry, University of Turku, Turku, Finland.ORCID 0000-0002-4120-1867
Roda Seseogullari-DirihanDepartment of Restorative Dentistry and Cariology, Adhesive Dentistry Research Group, Institute of Dentistry, University of Turku, Turku, Finland.ORCID 0000-0002-1484-6774
Mustafa Murat MutluayDepartment of Restorative Dentistry and Cariology, Adhesive Dentistry Research Group, Institute of Dentistry, University of Turku, Turku, Finland.ORCID 0000-0003-4131-1959
Arzu Tezvergil-MutluayDepartment of Restorative Dentistry and Cariology, Adhesive Dentistry Research Group, Institute of Dentistry, University of Turku, Turku, Finland.ORCID 0000-0003-0932-8531

Funding

Turku University Hospital #13140
6 · The paper itself

Abstract

This study aims to investigate the trans-dentinal and direct cell viability of ammonia- and water-based silver fluoride treatments. Deep dentin discs were prepared, balanced for permeability and autoclaved. Three-dimensional cultures of odontoblast-like cells were transferred to the pulpal aspect of the dentin slices inside perfusion split chambers designed for dentin-barrier cytotoxicity test, following ISO 7405. An experimental resin-based glass ionomer cement and a polyvinylsiloxane impression material served as positive and negative controls, respectively. The experimental treatments included: (i) ammonia-based silver fluoride = SDF, (ii) SDF + potassium iodide = KI, (iii) water-based silver fluoride = SF, and (iv) SF + KI. Treatments were applied to the occlusal surface of dentin discs and cell viability (%) was assessed after 24 h using the methylthiazolium (MTT) assay. The cytotoxicity of dilutions (10

Indexed as

AmmoniaCariostatic AgentsDentinFluoridesOdontoblastsSilver CompoundsCell LineCell SurvivalDentin PermeabilityFluoride TreatmentHumansTetrazolium SaltsThiazolesWaterAmmoniaCariostatic AgentsFluoridesSilver Compoundssilver fluorideTetrazolium SaltsThiazolesWateraqueous silver fluoridebiocompatibilitydentinpotassium iodidesilver diamine fluoride

Identifiers

PMID41299853
PMCPMC12819919

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.