Evidence map›Paper›PMID 41299788›Full record

ArticleMicrobiome2025

Abelmoschus Manihot flowers inhibit dysbiotic Enterobacteriaceae expansion by promoting Clostridium bolteae-mediated hypoxia restoration.

Chengxi Li, Yumeng Wang, Qinyu Zhang, Huashi Liang, Jianping Li, Shu Zhang, Jinao Duan, Jianming Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chengxi Li *Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Yumeng Wang *Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Qinyu ZhangJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Huashi LiangJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Jianping LiJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Shu ZhangJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Jinao DuanJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, China. dja@njucm.edu.cn.
Jianming GuoJiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, China. njuguo@njucm.edu.cn.

Funding

Key Project of National Natural Science Foundation Regional Innovation and Development U24A20794National Natural Science Foundation of China 82474166, 82074136
6 · The paper itself

Abstract

backgroundInflammatory bowel disease (IBD) is a chronic inflammatory disease that has become prevalent worldwide. Excessive expansion of Enterobacteriaceae is a key feature of dysbiosis in IBD patients, which further exacerbates intestinal inflammation. Therefore, inhibiting the dysbiotic expansion of Enterobacteriaceae is a promising strategy for the treatment of IBD. We investigated the effects of Abelmoschus manihot (A. manihot) flowers on the intestinal microbiota during colitis.

resultsWe found that A. manihot flowers are capable of ameliorating murine colitis and suppressing Enterobacteriaceae expansion, not by direct action but rather by promoting the growth of Lachnospiraceae, particularly Clostridium bolteae. Bacterial depletion and recolonization confirmed that Clostridium bolteae restored colonic hypoxia via PPAR-γ activation, creating an environment unfavorable for Enterobacteriaceae growth and reducing inflammation. Moreover, intestinal hypoxia is vital for Clostridium bolteae colonization and its effect on Enterobacteriaceae expansion, which involves crosstalk between gut microbe colonization and intestinal oxygen homeostasis.

conclusionOverall, our study provides evidence that modulating the gut microbiota to restore intestinal hypoxia is a promising therapeutic strategy for suppressing Enterobacteriaceae proliferation in the inflamed gut and for ameliorating intestinal inflammation, which could be applied to other Enterobacteriaceae-related diseases. Video Abstract.

Indexed as

AbelmoschusClostridiumColitisDysbiosisEnterobacteriaceaeFlowersGastrointestinal MicrobiomePlant ExtractsAnimalsDisease Models, AnimalHypoxiaInflammatory Bowel DiseasesMiceMice, Inbred C57BLPlant ExtractsAbelmoschus Manihot flowersClostridium bolteaeEnterobacteriaceaeGut microbiotaInflammatory bowel diseaseLachnospiraceaeOxygen leakage

Identifiers

PMID41299788
PMCPMC12763845

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.