Evidence map›Paper›PMID 41299759›Full record

ArticleParasites & vectors2025

Investigation of Cryptosporidium infection in a broad range of hosts in northern China.

Ziheng Liu, Jing Yang, Jiushikun Juman, Nannan Cui, Ligu Mi, Sándor Hornok, Guoyu Zhao, Quan Liu, Yuanzhi Wang

Abstract read
In one paragraph

Article in Parasites & vectors, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Molecular Characterization and Zoonotic Potential ofTransboundary and emerging diseases · 2026
    Article
  2. Molecular detection and phylogeny ofFrontiers in veterinary science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ziheng Liu *Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security of the XPCC, School of Medicine, Shihezi University, Shihezi, 832003, Xinjiang Uygur Autonomous Region, China.
Jing Yang *NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, Shihezi University, Shihezi, 832003, Xinjiang Uygur Autonomous Region, China.
Jiushikun Juman *Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security of the XPCC, School of Medicine, Shihezi University, Shihezi, 832003, Xinjiang Uygur Autonomous Region, China.
Nannan Cui *Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security of the XPCC, School of Medicine, Shihezi University, Shihezi, 832003, Xinjiang Uygur Autonomous Region, China.
Ligu MiKey Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security of the XPCC, School of Medicine, Shihezi University, Shihezi, 832003, Xinjiang Uygur Autonomous Region, China.
Sándor HornokDepartment of Parasitology and Zoology, University of Veterinary Medicine, Budapest, Hungary.
Guoyu ZhaoKey Laboratory of Vector-Borne Infectious Diseases, Center for Disease Control and Prevention, Urmqi, Xinjiang Uygur Autonomous Region, China.
Quan LiuKey Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security of the XPCC, School of Medicine, Shihezi University, Shihezi, 832003, Xinjiang Uygur Autonomous Region, China.
Yuanzhi WangKey Laboratory for Prevention and Control of Emerging Infectious Diseases and Public Health Security of the XPCC, School of Medicine, Shihezi University, Shihezi, 832003, Xinjiang Uygur Autonomous Region, China. wangyuanzhi621@126.com.

Funding

High-Level Talent Initiative Foundation of Shihezi University 2022ZK018Natural Science Key Project of Xinjiang Uygur Autonomous Region 2022B03014Science & Technology Innovation Team Project of TIANSHAN Elite 2023TSYCTD0020Scientific and Technological Projects in Key Areas of the Corps 2022AB014
6 · The paper itself

Abstract

backgroundCryptosporidium infection occurs in humans, domestic animals, and wildlife. To date, at least 49 species and 120 genotypes have been identified. Hitherto, molecular identification of Cryptosporidium species in wildlife has seldom been reported in China.

methodsDuring 2014-2025, a total of 1855 small intestinal or fecal specimens were collected from 1500 mammals, 121 reptiles, and 234 birds in Xinjiang Uygur Autonomous Region (XUAR) and Inner Mongolia Autonomous Region (IMAR), northern China. The identification of each animal species was based on morphological characteristics and mitochondrial gene amplification. Detection of Cryptosporidium species was performed by amplifying part of the small subunit (SSU) ribosomal RNA (rRNA) gene. The 60 kDa glycoprotein (GP60) gene was used to confirm their species and subtypes.

resultsThe samples were collected from 39 mammalian, 6 reptilian, and 30 avian species. In these samples, the average rate of infection with Cryptosporidium species was 8.09% (150/1855). In total, 18 known Cryptosporidium species and genotypes were identified, including Cryptosporidium hominis, Cryptosporidium ubiquitum, Cryptosporidium muris, Cryptosporidium canis, Cryptosporidium felis, Cryptosporidium equi, Cryptosporidium proventriculi, Cryptosporidium ryanae, Cryptosporidium rubeyi, chipmunk genotype V, vole genotype III, vole genotype V, muskrat genotype I, bat genotype IV, yak genotype, deer genotype, goose genotype I, and one unnamed Cryptosporidium sp. In addition, a novel genotype, here designated as Cryptosporidium Mongolian pika genotype, was identified in the Mongolian pika (Ochotona pallasi).

conclusionsInvestigation of Cryptosporidium infection was carried out by screening 75 animal species. Overall, 19 Cryptosporidium species and genotypes were detected, including a novel genotype in Mongolian pika and first-time diagnosis of this infection in several rodent species (e.g., red-cheeked ground squirrels, great gerbils, northern mole voles, and Libyan jirds).

Indexed as

CryptosporidiosisCryptosporidiumAnimalsAnimals, WildBirdsChinaDNA, ProtozoanFecesGenotypeHumansMammalsPhylogenyReptilesDNA, ProtozoanCryptosporidiumNorthern ChinaPCRWildlife

Identifiers

PMID41299759
PMCPMC12750556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.