Evidence map›Paper›PMID 41299752›Full record

SynthesisRadiation oncology (London, England)2025

Efficacy and safety of stereotactic radiosurgery for hypothalamic hamartomas: a systematic review and meta-analysis.

Bardia Hajikarimloo, Salem M Tos, Mohammadamin Sabbagh Alvani, Alireza Kooshki, Ibrahim Mohammadzadeh, Amir Hesam Zare, Amir Hosein Zare, Ali Mortezaei, Ehsan Bahrami Hezaveh, Azin Ebrahimi and 1 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Radiation oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bardia HajikarimlooDepartment of Neurological Surgery, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. bardii47@yahoo.com.
Salem M TosDepartment of Neurological Surgery, University of Virginia, Charlottesville, VA, USA.
Mohammadamin Sabbagh AlvaniDepartment of Neurological Surgery, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Alireza KooshkiStudent Research Committee, Birjand University of Medical Sciences, Birjand, Iran.
Ibrahim MohammadzadehSkull Base Research Center, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Amir Hesam ZareDepartment of Neurological Surgery, Tehran University of Medical Sciences, Tehran, Iran.
Amir Hosein ZareDepartment of Neurological Surgery, Tehran University of Medical Sciences, Tehran, Iran.
Ali MortezaeiStudent Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran.
Ehsan Bahrami HezavehDepartment of Neurological Surgery, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Azin EbrahimiDepartment of Neurological Surgery, Shohada Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mohammad Amin HabibiDepartment of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypothalamic hamartomas (HHs) are congenital, non-neoplastic tumors originating from the hypothalamic region. While surgical resection remains the standard treatment, it is associated with substantial morbidity, leading to the exploration of minimally invasive approaches such as radiofrequency thermocoagulation (RFTC), laser interstitial thermal therapy (LiTT), and stereotactic radiosurgery (SRS). This systematic review and meta-analysis evaluate the efficacy and safety of SRS in managing HHs, with a focus on seizure control, endocrine function, and treatment-related complications.

methodsA comprehensive literature search was conducted on December 6, 2024, using PubMed, Embase, Scopus, and Web of Science. Studies that evaluated the role of SRS in HH patients were included. The R program was used to calculate the pooled estimates.

resultsSeven studies with 152 HH patients were included. The meta-analysis revealed a pooled post-SRS seizure improvement rate of 77% (95% CI: 61%-91%) and a seizure-free status rate of 48% (95% CI: 19%-78%). In addition, the meta-analysis showed a pooled good outcome, Engel I/II, rate of 67% (95% CI: 48%-84%), and a pooled adverse radiation effect (ARE) rate of 0% (95% CI: 0%-1%).

conclusionSRS provides favorable seizure control and a promising safety profile for managing patients with HH. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

HamartomaHypothalamic DiseasesRadiosurgeryHumansTreatment OutcomeAdverse radiation effectHypothalamic hamartomaMeta-analysisRadiosurgerySeizure

Identifiers

PMID41299752
PMCPMC12659174

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.