ArticleTrials2025
HPV self-sampling for cervical cancer screening among women living with HIV in Ghana: protocol for a hybrid type 1 effectiveness-implementation randomized controlled trial.
Article in Trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06739772 (Development of Implementation Toolkits to Promote HPV Self-sampling Behavior Among Women Living With HIV in Ghana), which is not on this map. Cited by 3 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Development of Implementation Toolkits to Promote HPV Self-sampling Behavior Among Women Living With HIV in Ghana
Who cites it
3 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundWomen living with HIV (WLWH) face a significantly higher risk of developing cervical cancer (CC) due to immune system suppression, which impairs the body's ability to clear high-risk HPV infections. Despite this increased risk, cervical cancer screening rates remain low among WLWH in Ghana, hindered by financial, logistical, and cultural barriers. Evidence-based interventions, such as HPV self-sampling and the 3R communication model (reframe, reprioritize, and reform) offer promising strategies to improve screening uptake. The primary objective of this study was to evaluate the effectiveness of the Home-based self-sampling for cervical cancer Prevention Education (HOPE) toolkit in increasing CC screening among WLWH in Ghana. Secondary objectives include assessing the feasibility, acceptability, appropriateness and adoptability of the HOPE intervention, as well as identifying key factors that influence its implementation.
methodsThe study will be conducted at the Cape Coast Teaching Hospital (CCTH) in Ghana, using a Hybrid Type 1 effectiveness-implementation randomized controlled trial (RCT) design. A total of 108 WLWH will be randomly assigned to either the HOPE intervention group, which includes HPV self-sampling and 3R messaging, or a control group receiving standard care. Data will be collected through structured surveys, key informant interviews, and focus group discussions. The study will also engage a stakeholder advisory board (SAB) comprising WLWH, healthcare providers and community members to co-develop and adapt the intervention through nominal group technique. DISCUSSION: By leveraging existing healthcare infrastructure and community engagement, this study seeks to provide a scalable, evidence-based approach to improving CC screening among WLWH in Ghana. Findings will inform national strategies for integrating HPV self-sampling and health communication interventions to enhance early detection and reduce cervical cancer-related morbidity and mortality in this high-risk population.
trial registrationClinicalTrials.gov NCT06739772. Registered on 18 December 2024.
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