ArticleBiomedical engineering online2025
Inhibition of Na
Article in Biomedical engineering online, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Acute and sub-acute toxicity assessment of tetrodotoxin in Sprague-Dawley rats following intramuscular injection.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe Na
methodsTTX was extracted using 2% acetic acid-methanol (v/v). To determine the lethal concentration of TTX, three concentrations of the TTX extract (1.5, 2.0, and 3.0 mg/kg) were injected into transgenic mice that had already been induced by the 4T1 cell line and bearing tumors. After 7-8 weeks of monitoring tumor volume, the mice were killed, and a portion of the tumors was fixed in Bouin's fixative for immunohistological analysis, while the rest was frozen for biochemical analysis.
resultsBiometric analysis of Balb/c nu mice indicated a notable reduction in tumor volume progression in the group subjected to TTX extract compared to the control group. Furthermore, immunohistochemical and biochemical analysis demonstrated a decrease in the intensity and activity of NKA in the TTX extract group compared to the control group.
conclusionOur results indicate that TTX extract may have anti-tumor effects by inhibiting NKA activity. Therefore, considering the presence of TTX in the pufferfish extract, TTX could be a promising therapeutic candidate for controlling metastatic breast tumor growth and metastasis through NKA inhibition.
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Registered trials
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