Evidence map›Paper›PMID 41299653›Full record

ArticleMolecular autism2025

The impact of camouflaging autistic traits on psychological and physiological stress: a co-twin control study.

Sabela Conde-Pumpido Zubizarreta, Johan Isaksson, Åshild Faresjö, Tomas Faresjö, Angel Carracedo, Montse Fernández Prieto, Sven Bölte, Karl Lundin Remnélius

Abstract readTwin Study
In one paragraph

Article in Molecular autism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sabela Conde-Pumpido ZubizarretaGenomics and Bioinformatics Group, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela (USC), Santiago de Compostela, Spain.
Johan IsakssonCenter of Neurodevelopmental Disorders (KIND), Department of Women's and Children's Health, Center for Psychiatry Research, Karolinska Institutet & Region Stockholm, Stockholm, Sweden.
Åshild FaresjöDepartment of Health, Medicine and Caring Sciences, Division of Society and Health, Linköping University, Linköping, Sweden.
Tomas FaresjöDepartment of Health, Medicine and Caring Sciences, Division of Society and Health, Linköping University, Linköping, Sweden.
Angel CarracedoGenomics and Bioinformatics Group, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela (USC), Santiago de Compostela, Spain.
Montse Fernández PrietoGenomics and Bioinformatics Group, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela (USC), Santiago de Compostela, Spain.
Sven BölteCenter of Neurodevelopmental Disorders (KIND), Department of Women's and Children's Health, Center for Psychiatry Research, Karolinska Institutet & Region Stockholm, Stockholm, Sweden.
Karl Lundin RemnéliusCenter of Neurodevelopmental Disorders (KIND), Department of Women's and Children's Health, Center for Psychiatry Research, Karolinska Institutet & Region Stockholm, Stockholm, Sweden. karl.lundin.remnelius@ki.se.ORCID 0000-0002-0270-8358

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCamouflaging autistic traits is suggested to increase stress and the risk of autistic burnout. However, the relationship with psychological and biological markers of stress and the influence of familial factors on this relationship remain unclear.

methodsIn a neurodiverse twin sample (N = 315; 69 diagnosed with autism), we examined associations between camouflaging behaviors (operationalized as the discrepancy between the Autism Diagnostic Observation Schedule 2nd edition [ADOS-2] and the Autism Quotient [AQ]), rated stress-related symptoms, and biological long-term stress measured via hair cortisol concentration (HCC). Associations were analyzed across the full sample, accounting for age, sex, and HCC confounders, as well as within-twin pairs, implicitly adjusting for genetic and environmental confounding.

resultsAcross individuals, camouflaging was associated with increased HCC, particularly in autistic and adult subsamples, while associations with stress-related symptoms were only evident in adults. Within-pair analyses revealed no associations in the full sample, suggesting familial confounding. Interestingly, in adjusted within-pair models in autistic and adult twin-pairs, camouflaging was linked to lower HCC. LIMITATIONS: Only the adult participants provided self-reports of autistic traits (AQ) and stress-related symptoms, while parent-reports were used for the younger participants. This difference in reporting sources may have reduced the accuracy of data for the younger subgroups in our sample.

conclusionsThe findings indicate that camouflaging is associated with increased biological long-term stress at the population level but that familial factors may influence this relationship. Future research is needed to explore these complex dynamics and their implications for mental health and adaptive functioning in autistic individuals.

Indexed as

Autistic DisorderStress, PhysiologicalStress, PsychologicalAdolescentAdultFemaleHairHumansHydrocortisoneMaleMiddle AgedYoung AdultHydrocortisoneAutismCamouflagingCortisolHair cortisol concentrationMaskingStress

Identifiers

PMID41299653
PMCPMC12659362

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.