Evidence map›Paper›PMID 41299619›Full record

ArticleJournal of nanobiotechnology2025

A simple and effective hydrogel dressing for advanced management of full-thickness skin wound by multi-functional strategies.

Deqiao Dong, Lujia Mao, Zhenmiao Qin, Yueping Guo, Jiaqi Yu, Xue Hu, Jie He, Shiquan Feng, Min Zhang, Yan Liu and 1 more

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Deqiao Dong *Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education & Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, Hainan, China.
Lujia Mao *Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education & Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, Hainan, China.
Zhenmiao Qin *Engineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education & Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, Hainan, China.
Yueping GuoThe Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China.
Jiaqi YuEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education & Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, Hainan, China.
Xue HuEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education & Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, Hainan, China.
Jie HeEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education & Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, Hainan, China.
Shiquan FengEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education & Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, Hainan, China.
Min ZhangEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education & Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, Hainan, China. minzhang@muhn.edu.cn.
Yan LiuEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education & Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, Hainan, China. liu_yan@muhn.edu.cn.
Yanan GaoEngineering Research Center of Tropical Medicine Innovation and Transformation of Ministry of Education & Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, Hainan, China. gao_yanan@muhn.edu.cn.

Funding

Hainan Provincial Natural Science Foundation of China No. 821RC569Innovative Research Projects for Graduate Students of Hainan Medical University No. HYYB2023A38National Natural Science Foundation of China No. 82060642
6 · The paper itself

Abstract

In clinical practice, wound treatment continues to be a significant concern. The wound healing process is intricate and continuous. Hemostasis is the initial stage and the primary variables influencing wound healing include bacterial infection and oxidative stress. To tackle these issues, a novel hydrogel dressing was constructed, composed of chitosan hydrochloride (CSCl), hydroxyethyl cellulose (HEC), glucose and resveratrol nanoemulsion (RES-NE). The innovative RES-NE loaded chitosan hydrogel (RN-CH) features controllable gelation time, rapid self-healing property, appropriate injectability, and strong tissue adhesion ability. Additionally, it exhibits excellent biocompatibility, antioxidant property, antibacterial activity, and significant hemostasis capability. Pharmacodynamic experiments reveal that RN-CH can effectively promote full-thickness wounds healing by modulating inflammation, mitigating oxidative stress, and facilitating early angiogenesis and collagen formation.

Indexed as

BandagesHydrogelsSkinWound HealingAnimalsAnti-Bacterial AgentsAntioxidantsCelluloseChitosanGlucoseHumansMaleMiceOxidative StressResveratrolAnti-Bacterial AgentsAntioxidantsCelluloseChitosanGlucoseHydrogelshydroxyethylcelluloseResveratrolAntibacterialAnti-inflammatoryAntioxidantChitosan-HEC-glucose hydrogelExcellent biocompatibility

Identifiers

PMID41299619
PMCPMC12659538

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.