Evidence map›Paper›PMID 41299591›Full record

ArticleScandinavian journal of trauma, resuscitation and emergency medicine2025

Indicators of early transfusion in paediatric trauma: a retrospective analysis of 11,849 cases from the TraumaRegister DGU

Niko R E Schneider, Ralf Kraus, Rolf Lefering, Fabian Hemm, Davut Deniz Uzun, Christan Heiss, Andreas Hecker, Michael Sander, TraumaRegister DGU®, Emmanuel Schneck

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scandinavian journal of trauma, resuscitation and emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Early transfusion strategies in haemorrhagic shock.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Niko R E SchneiderDepartment of Anesthesiology, Operative Intensive Care Medicine and Pain Therapy, University Hospital of Giessen, Justus-Liebig-University of Giessen, Giessen, Germany.
Ralf KrausDepartment of Trauma-, Hand- and Reconstructive Surgery, University Hospital of Giessen, Justus-Liebig-University of Giessen, Giessen, Germany.
Rolf LeferingInstitute for Research in Operative Medicine (IFOM), University Witten/Herdecke, Cologne, Germany.
Fabian HemmDepartment of Trauma-, Hand- and Reconstructive Surgery, University Hospital of Giessen, Justus-Liebig-University of Giessen, Giessen, Germany.
Davut Deniz UzunMedical Faculty Heidelberg, Department of Anesthesiology, Heidelberg University, Heidelberg, Germany.
Christan HeissDepartment of Trauma-, Hand- and Reconstructive Surgery, University Hospital of Giessen, Justus-Liebig-University of Giessen, Giessen, Germany.
Andreas HeckerDepartment of General, Thoracic and Transplant Surgery, University Hospital of Giessen, Justus-Liebig-University of Giessen, Giessen, Germany.
Michael SanderDepartment of Anesthesiology, Operative Intensive Care Medicine and Pain Therapy, University Hospital of Giessen, Justus-Liebig-University of Giessen, Giessen, Germany.
TraumaRegister DGU®
Emmanuel SchneckDepartment of Anesthesiology, Operative Intensive Care Medicine and Pain Therapy, University Hospital of Giessen, Justus-Liebig-University of Giessen, Giessen, Germany. emmanuel.schneck@chiru.med.uni-giessen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe transfusion of red blood cell (RBC) concentrates represents an emerging approach in paediatric trauma management, even in the prehospital period. Nevertheless, distinctive parameters for predicting the need for transfusion in children are still lacking. This study aimed to identify indicators for early in-hospital RBC transfusions that are primarily accessible either in the prehospital or in the early in-hospital setting in a large paediatric trauma cohort.

methodsThis study comprised a retrospective analysis of the German TraumaRegister DGU

resultsA total of 11,849 patients were included, with RBC transfusion performed in 5.9% of cases. Polytraumatised patients (adjusted odds ratio (adj. OR) 4.18 [95% confidence interval 3.26-5.34]) and those with penetrating injuries (adj. OR 4.32 [2.96-6.30]) and abdominal injuries (adj. OR 4.18 [3.34-5.24]) exhibited the highest risk of requiring an RBC transfusion. The need for cardiopulmonary resuscitation (adj. OR 2.46 [1.84-3.28]), endotracheal intubation (adj. OR 2.51 [1.93-3.28]), and Glasgow Coma Scale (GCS) ≤ 8 (adj. OR 2.49 [1.85-3.36]) were also significant, but weaker, predictors. A model based on the mentioned parameters achieved an area under the ROC curve of 0.87 [0.85-0.88], whereas predictive performance was lower but still acceptable when only parameters available in the prehospital setting were included (AUC 0.80 [0.78-0.82]).

conclusionThe likelihood of requiring an RBC transfusion is increased in cases of polytrauma, abdominal and penetrating trauma, patients with a GCS ≤ 8, and those requiring tracheal intubation or cardiopulmonary resuscitation. Therefore, the proposed risk factors can help identify patients at risk of severe haemorrhage and subsequent transfusion requirement. CLINICAL TRIAL NUMBER: Not applicable.

Indexed as

Erythrocyte TransfusionRegistriesWounds and InjuriesAdolescentAustriaChildChild, PreschoolFemaleGermanyHumansInfantInjury Severity ScoreMaleRetrospective StudiesRisk FactorsROC CurveChildrenEmergency medicineHaemorrhagePaediatric traumaRed blood cell concentrate

Identifiers

PMID41299591
PMCPMC12676769

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.