ArticleBMC public health2025
Prospective associations between nicotine type and the continuation of youth e-cigarette use.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundE-cigarettes can contain either "tobacco derived" nicotine, which is comprised of almost entirely S-nicotine isomers, or "synthetic" nicotine, which is comprised of a mixture of R- and S-nicotine isomers ("R/S" nicotine). Emerging studies suggest R/S nicotine may be less pharmacologically potent, which could indicate a lower addictive potential. The purpose of the present study was to examine whether e-cigarette brands containing different nicotine types are associated with the continuation of youth's e-cigarette use.
methodsData came from a prospective cohort study of youth. Analyses were restricted to youth (ages 16-24; N = 216) who, at their baseline assessment in 2021, were using either JUUL (S-nicotine) or Puff Bar (R/S nicotine) e-cigarettes. Multivariable logistic regression tested whether nicotine type at baseline was associated with past-30-day e-cigarette use at the 12-month follow-up.
resultsCompared to participants who used Puff Bar, participants who used JUUL had higher odds of continued use at the 12-month-follow-up (aOR, 1.93, 95% CI, 1.07-3.45, p = 0.029).
conclusionOur findings suggest that, when it comes to predicting the continuation of vaping among youth who have already initiated, nicotine type (i.e., the ratio of R- and S-isomers) may play a critical role. It is encouraging that R/S nicotine may have lower addictive potential; however, tobacco control should be vigilant for marketing strategies attempting to establish R/S nicotine e-cigarettes as "starter" products for youth.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.