ArticleBMC medicine2025
Higher adherence to (poly)phenol-rich diet is associated with lower CVD risk in the TwinsUK cohort.
Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Iron Nitrates Stimulate Phenolic Compound Production byInternational journal of molecular sciences · 2026Article
- The Triangular Interaction Between Dietary Polyphenols, Gut Microbiota and Type 2 Diabetes.International journal of molecular sciences · 2026Review
- The Gut Microbiota-Polyphenol-NLRP3 Inflammasome Axis: A Key Regulatory Network Linking Diet to Chronic Inflammation.Nutrients · 2026Review
- The Potential Role of Dietary (Poly)phenols in Cardiometabolic Risk During Menopause: A Narrative Review.Nutrients · 2026Review
- Article
- Association between triglyceride-glucose index-a body shape index and atherosclerotic cardiovascular disease, and the modification effect of dietary patterns.Frontiers in nutrition · 2026Article
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Authors and funding
12 authors.
Funding
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Abstract
backgroundPrevious studies have reported inverse associations between total (poly)phenol intake or specific subclasses of (poly)phenols, estimated from dietary questionnaires, and cardiovascular disease (CVD) risk. However, no studies have examined (poly)phenol-rich dietary patterns and their corresponding urinary metabolite profiles in relation to CVD risk. This study investigated the associations between a (poly)phenol-rich dietary score (PPS-D), its urinary metabolic signature (PPS-M), and longitudinal CVD risk in the TwinsUK cohort.
methodsWe included 3110 participants (followed up for 11.20 ± 7.03 years) from TwinsUK who completed the EPIC-Norfolk Food Frequency Questionnaire with longitudinal data. A subset of 200 participants provided spot urine samples, in which 114 (poly)phenol metabolites were quantified using ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS) to objectively measure (poly)phenol exposure. Associations between the PPS-D or PPS-M and CVD risk scores (ASCVD risk score and HeartScore), and biomarkers of CVD risk (blood pressure and lipid profile) were assessed using linear mixed models, adjusting for covariates and multiple testing (FDR < 0.05).
resultsPPS-D was negatively associated with ASCVD risk score (stdBeta: - 0.05 (- 0.07, - 0.04)) and Heartscore (stdBeta: - 0.03 (- 0.04, - 0.01)) (FDR-adjusted p < 0.01) in the overall population (n = 3,110). In the subgroup with urinary metabolites (n = 200), such significant associations were partially replicated through metabolites of flavonoids, phenolic acids, and tyrosols that significantly negatively associated with the ASCVD risk score, HeartScore, diastolic blood pressure (DBP), and positively with high-density lipoprotein cholesterol (HDL-C). In addition, a higher PPS-M was correlated with elevated HDL-C and lower blood pressure, ASCVD risk score, and HeartScore.
conclusionsHigher adherence to a (poly)phenol-rich diet is associated with lower CVD risk, with consistent associations observed through urinary metabolite profiles, highlighting the long-term cardiovascular benefits of (poly)phenol consumption, particularly flavonoids and phenolic acids.
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