Trial reportBMC anesthesiology2025
Effects of different bupivacaine concentrations with dural puncture epidural technique for labor analgesia: a prospective randomized controlled trial.
Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05499234 (Effects of Different Local Anesthetic Concentrations With Epidural Tap Method for Labor Analgesia), which is not on this map. Not yet cited in PubMed.
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Effects of Different Local Anesthetic Concentrations With Epidural Tap Method for Labor Analgesia
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5 authors.
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Abstract
backgroundDural puncture epidural (DPE) is a newer and more advantageous method in labor analgesia. It provides a faster analgesia onset and higher-quality block compared to the conventional epidural (CE) method, while causing fewer adverse effects than the combined spinal-epidural (CSE) technique. This study aims to compare the effects of bupivacaine at different concentrations, but equal volumes administered via DPE on the mother, fetus, and labor process, and reduce total bupivacaine requirement and its potential side effects.
methodsSeventy ASA II primigravid pregnant women with cervical dilatation between 4 and 6 cm were included in the study. Participants were randomly divided into two groups. Group 1 received a high concentration of bupivacaine (0.125%) + 2 mcg/mL fentanyl; Group 2 received a low concentration of bupivacaine (0.0625%) + 2 mcg/mL fentanyl, both using DPE. The numeric rating scale (NRS) score was aimed to be < 4. The total amount of bupivacaine and fentanyl administered through the epidural catheter, the time between applications, the time between applications and birth, the number of doses administered, complications, maternal vital signs, fetal heart rate and maternal satisfaction were recorded.
resultsThe mean amount of bupivacaine administered was 31.7 ± 7.6 mg in Group 1 and 15.1 ± 3.4 mg in Group 2, showing a significant difference (P = 0.001, Mean ± SD, Student's t test). There were no significant differences in NRS scores, duration between doses, duration between doses and delivery, satisfaction, and complications.
conclusionThis study compared the effects of different bupivacaine concentrations with DPE and found that using low-concentration bupivacaine (0.0625%) for labor provides adequate analgesia without increasing complications or delivery time while reducing the amount of bupivacaine needed.
trial registrationRegistration number: NCT05499234. Registration date: 2022-08-02 (Retrospectively registered). Registration URL: https://clinicaltrials.gov/ct2/show/NCT05499234 .
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