Evidence map›Paper›PMID 41299372›Full record

ArticleBMC oral health2025

Impact of sodium hypochlorite on the dissolution of soft tissue with photon-initiated photoacoustic streaming (PIPS) activation.

Runjie Hu, Yuting Huang, Chen Cai, Yu Cheng, Huixian Dong, Lanxi Guan, Qianzhou Jiang

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In one paragraph

Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Runjie Hu *Department of Endodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.
Yuting Huang *Department of Endodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.
Chen CaiDepartment of Endodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.
Yu ChengDepartment of Endodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.
Huixian DongDepartment of Endodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.
Lanxi GuanDepartment of Endodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China.
Qianzhou JiangDepartment of Endodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China. jqianzhou@126.com.

Funding

GuangDong Basic and Applied Basic Research Foundation Project 2022A1515110601Guangzhou Municipal Science and Technology Bureau, Basic and Applied Basic Special Research Project 2024A04J3387
6 · The paper itself

Abstract

backgroundThis study aimed to investigate the effect of different sodium hypochlorite (NaOCl) concentrations on the efficacy of tissue dissolution with PIPS activation in artificial root canal models.

methodsArtificial root canal models were divided into eight groups (n = 30/group), based on irrigation method (conventional needle irrigation or PIPS) and irrigant concentration (saline, 1% NaOCl, 2.5% NaOCl, and 5.25% NaOCl). Irrigation was performed using standardized protocols. Soft tissue samples were obtained from porcine palatal mucosa and placed at coronal 1/3, middle 1/3 and apical 1/3 of the root canal. Tissue dissolution was quantified by measuring weight loss of each tissue sample. Free available chlorine (FAC), pH and temperature of irrigant were also assessed. For normally distributed data, factorial repeated measures analysis of variance (ANOVA) and Least-Significant Difference (LSD) comparison were used. Paired t-test and Wilcoxon signed-rank test were used to assess tissue dissolution after irrigation.

resultsPIPS activation contributed to significantly higher mass reduction percentage of tissue samples (p <.05). 5.25% NaOCl exhibited the highest mass reduction percentage of all irrigants under PIPS activation. The highest dissolution occurred with 5.25% NaOCl under PIPS, achieving near-complete tissue dissolution in the apical third. Decrease in pH and increase in temperature of NaOCl after irrigation were also observed.

conclusionsNaOCl showed greater tissue dissolving efficacy under PIPS activation than CNI. The tissue dissolving ability of NaOCl increased as the concentration increased. PIPS demonstrates superior apical irrigation efficiency compared to CNI, highlighting its clinical potential.

Indexed as

Mouth MucosaPhotoacoustic TechniquesRoot Canal IrrigantsSodium HypochloriteAnimalsHydrogen-Ion ConcentrationPhotonsSwineTemperatureTherapeutic IrrigationRoot Canal IrrigantsSodium HypochloritePhoton-initiated photoacoustic streaming (PIPS)Sodium hypochloriteTissue dissolution

Identifiers

PMID41299372
PMCPMC12659270

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.