Evidence map›Paper›PMID 41299326›Full record

ArticleBMC cancer2025

[

Lianne Triemstra, Sarah W J M Spruijt, Dennis Vriens, Erik Vegt, Wilma E Mesker, Lukas J A C Hawinkels, Sopany Saing, Marije Slingerland, Vera Kemp, Stijn A L P Crobach and 25 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07018661 ([18F]F-FAPI PET/CT and LAparoscopy in STagIng Advanced Gastric Cancer - a Multicenter Prospective Study), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07018661 phase2 / phase3recruitingnot on this map

[18F]F-FAPI PET/CT and LAparoscopy in STagIng Advanced Gastric Cancer - a Multicenter Prospective Study

TypeinterventionalSponsorLeiden University Medical CenterRan2025 to 2029Enrolled250ConditionsLocally Advanced Gastric Adenocarcinoma, STOMACH NEOPLASM, Gastric Cancer, PET-CTArms[18F]FAPI-74 PET/CT, [18F]-FAPI-74
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Lianne Triemstra *Department of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-7057-0274
Sarah W J M Spruijt *Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0009-0001-6902-2182
Dennis VriensDepartment of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0001-5762-6766
Erik VegtDepartment of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7456-2258
Wilma E MeskerDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-5533-4778
Lukas J A C HawinkelsDepartment of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-2274-9325
Sopany SaingDepartment of Health Technology and Services Research, Faculty of Behavioural Management and Social Sciences, University of Twente, Enschede, The Netherlands.ORCID http://orcid.org/0000-0001-5913-9654
Marije SlingerlandDepartment of Medical Oncology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-4181-8656
Vera KempDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-4910-4655
Stijn A L P CrobachDepartment of Pathology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-1289-4406
Jelle J GoemanDepartment of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-4283-0259
Martin PoolDepartment of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-4892-3109
Petra Dibbets-SchneiderDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-0538-8270
Roel J BenninkDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-1196-1416
Mark I van Berge HenegouwenDepartment of Surgery, Amsterdam UMC Location University of Amsterdam, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0001-8689-3134
Marc J van DetDepartment of Surgery, Ziekenhuisgroep Twente, Almelo, The Netherlands.ORCID http://orcid.org/0000-0002-7338-2818
Boudewijn J van EttenDepartment of Surgery, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-2900-2942
Henk H HartgrinkDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-0015-8556
Richard van HillegersbergDepartment of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-7134-261X
Marnix G E H LamDepartment of Radiology and Nuclear Medicine, UMC Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0002-4902-9790
Nanda M SmuldersDepartment of Nuclear Medicine, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.
Misha D P LuyerDepartment of Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.ORCID http://orcid.org/0000-0002-9483-1520
Walter NoordzijDepartment Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-6386-5499
Emilia C OwersDepartment of Nuclear Medicine, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.ORCID http://orcid.org/0009-0008-5242-2340
Wim J G OyenDepartment of Radiology and Nuclear Medicine, Rijnstate Hospital, Arnhem, The Netherlands.ORCID http://orcid.org/0000-0001-8235-7078
Johanna W van SandickDepartment of Surgical Oncology, Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-1208-6388
Wendy SchreursDepartment of Nuclear Medicine, Zuyderland Medical Center, Heerlen, The Netherlands.
Wobbe O de SteurDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-8095-7798
Jan H M B StootDepartment of Surgery, Zuyderland Medical Center, Heerlen, The Netherlands.ORCID http://orcid.org/0000-0003-3178-0049
Leo E WeijsDepartment of Nuclear Medicine, Ziekenhuisgroep Twente, Almelo, The Netherlands.
Bas P L WijnhovenDepartment of Surgery, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-4738-3697
Bart P L WittemanDepartment of Surgery, Rijnstate Hospital, Arnhem, The Netherlands.
Jelle P RuurdaDepartment of Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-6584-1677
Lioe-Fee de Geus-OeiDepartment of Radiology, Leiden University Medical Center, Leiden, The Netherlands. l.oei@utwente.nl.ORCID http://orcid.org/0000-0003-1817-2743
PLASTIC-3 Study Group

Funding

KWF Kankerbestrijding 15400
6 · The paper itself

Abstract

backgroundTreatment decisions for locally advanced gastric adenocarcinoma rely on staging with gastroscopy, computed tomography (CT), and staging laparoscopy (SL). However, CT often fails to detect peritoneal and other distant metastases, and SL is an invasive procedure with complication risks and costs. Therefore, an accurate non-invasive imaging biomarker to detect such metastases could improve the care for gastric cancer patients. Radiolabeled fibroblast-activating protein inhibitors (FAPI), targeting stromal cancer-associated fibroblasts, are promising radiotracers. Preliminary Asian studies indicate that FAPI PET/CT outperforms [

methodsThis Dutch multicenter prospective clinical trial will recruit 250 patients with resectable, locally advanced gastric adenocarcinoma (cT3-4N0-3M0) as determined by gastroscopy and CT, planned for curative treatment. The modality under investigation is [ DISCUSSION: This study hypothesizes that [

trial registrationClinicalTrials.gov, NCT07018661. This trial was registered prospectively on June 12th, 2025.

Indexed as

AdenocarcinomaLaparoscopyPositron Emission Tomography Computed TomographyStomach NeoplasmsFemaleFluorine RadioisotopesHumansMaleMulticenter Studies as TopicNeoplasm StagingProspective StudiesRadiopharmaceuticalsFluorine RadioisotopesRadiopharmaceuticalsGastrectomyGastric cancerLaparoscopyPET-CTRadiopharmaceuticals

Identifiers

PMID41299326
PMCPMC12836824

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.