Evidence map›Paper›PMID 41299312›Full record

ArticleBMC pediatrics2025

The impact of pediatric constipation on appendicitis: a prospective birth cohort in the Japan Environment and Children's Study.

Hiroyoshi Iwata, Takeshi Yamaguchi, Sachiko Itoh, Yu Ait Bamai, Atsuko Ikeda, Keitaro Makino, Mariko Itoh, Maki Tojo, Rieko Yamamoto, Naomi Tamura and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hiroyoshi IwataCenter for Environmental and Health Sciences, Hokkaido University, North-12, West-7, Kita-Ku, Sapporo, 060-0812, Japan. hiroyoshi-Iwata@cehs.hokudai.ac.jp.
Takeshi YamaguchiCenter for Environmental and Health Sciences, Hokkaido University, North-12, West-7, Kita-Ku, Sapporo, 060-0812, Japan.
Sachiko ItohCenter for Environmental and Health Sciences, Hokkaido University, North-12, West-7, Kita-Ku, Sapporo, 060-0812, Japan.
Yu Ait BamaiCenter for Environmental and Health Sciences, Hokkaido University, North-12, West-7, Kita-Ku, Sapporo, 060-0812, Japan.
Atsuko IkedaCenter for Environmental and Health Sciences, Hokkaido University, North-12, West-7, Kita-Ku, Sapporo, 060-0812, Japan.
Keitaro MakinoCenter for Environmental and Health Sciences, Hokkaido University, North-12, West-7, Kita-Ku, Sapporo, 060-0812, Japan.
Mariko ItohCenter for Environmental and Health Sciences, Hokkaido University, North-12, West-7, Kita-Ku, Sapporo, 060-0812, Japan.
Maki TojoCenter for Environmental and Health Sciences, Hokkaido University, North-12, West-7, Kita-Ku, Sapporo, 060-0812, Japan.
Rieko YamamotoCenter for Environmental and Health Sciences, Hokkaido University, North-12, West-7, Kita-Ku, Sapporo, 060-0812, Japan.
Naomi TamuraCenter for Environmental and Health Sciences, Hokkaido University, North-12, West-7, Kita-Ku, Sapporo, 060-0812, Japan.
Rahel Mesfin KetemaCenter for Environmental and Health Sciences, Hokkaido University, North-12, West-7, Kita-Ku, Sapporo, 060-0812, Japan.
Yasuaki SaijoDepartment of Social Medicine, Asahikawa Medical University, 1-1-1 Midorigaoka-Higashi-2-Jo, Asahikawa, 078-8510, Japan.
Yoshiya ItoFaculty of Nursing, Japanese Red Cross Hokkaido College of Nursing, 664-1 Akebono-Cho, Kitami, 090-0011, Japan.
Reiko KishiCenter for Environmental and Health Sciences, Hokkaido University, North-12, West-7, Kita-Ku, Sapporo, 060-0812, Japan.
Japan Environment and Children’s Study (JECS) Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to examine the association between constipation and appendicitis in children using data from a nationwide birth cohort, the Japan Environment and Children's Study (JECS).

methodsData were obtained from 64,772 children and their mothers participating in JECS, which included over 100,000 pregnancies across 15 regional centres in Japan. Pediatric constipation was assessed at age three using the Rome III criteria, while appendicitis cases were identified between ages three to four. Logistic regression analyses, including univariable and multivariable models, were conducted to evaluate associations. Additional analyses were stratified by sex.

resultsAmong the 64,772 children analyzed, 156 cases of appendicitis were identified between the ages of 3 and 4 years. Logistic regression suggested a possible association between constipation and an increased risk of appendicitis (univariable odds ratio [OR]: 1.38, 95% confidence interval [CI]: 0.87–2.10; multivariable OR: 1.36, 95% CI: 0.86–2.06). Although the associations did not reach statistical significance, the point estimates consistently indicated a trend toward increased risk.

conclusionAlthough our analyses of children aged 3–4 years did not yield statistically significant associations, the observed trends may suggest a potential link between constipation and appendicitis. These findings should be interpreted only as exploratory, and further studies in different age groups, including older children and adults, are warranted to confirm or refute this possible association.

Indexed as

AppendicitisConstipationBirth CohortChild, PreschoolFemaleHumansJapanLogistic ModelsMaleProspective StudiesRisk FactorsAppendicitisConstipationJapan Environment and Children’s Study

Identifiers

PMID41299312
PMCPMC12649063

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.