SynthesisBMC gastroenterology2025
Long-term prognostic value of postoperative C-reactive protein in gastric cancer patients: a systematic review and meta-analysis.
Synthesis in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- A nomogram for predicting progression-free survival in stage III-IV gastric cancer based on post-treatment cholinesterase and C-reactive protein.Journal of gastrointestinal oncology · 2026Article
- Nutritional-C-reactive protein ratio as a prognostic marker in gastric cancer: a multicenter study.Frontiers in nutrition · 2026Article
- Combined Inflammatory Burden Index and hand grip strength for prognostic assessment in gastric cancer patients: a multicenter cohort study.Frontiers in nutrition · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundC-reactive protein (CRP) has begun to be used in clinical practice to predict the prognosis of cancer patients, but evidence on its prognostic role remains inconsistent. We performed a systematic review and meta-analysis to investigate the prognostic value of postoperative CRP among patients with gastric cancer.
methodsWe systematically searched PubMed, Embase, Web of Science, the Cochrane Library, Scopus, the Chinese National Knowledge Infrastructure (CNKI), Wan Fang Data, and the VIP Database for studies published from inception to April 30, 2025. Studies investigating the association between postoperative CRP and overall survival (OS) or recurrence-free survival (RFS) were included. Hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for these outcomes were extracted for meta-analysis.
resultsTwelve eligible cohort studies, involving 9246 patients, were included in the meta-analyses. Elevated postoperative CRP was a significant predictor of OS and RFS in gastric cancer patients (HR:1.51, 95% CI:1.38-1.66; HR:1.44, 95% CI:1.27-1.63, respectively). CRP measured at a specific postoperative time point showed stronger prognostic value (HR:1.74, 95% CI:1.37-2.19), despite substantial heterogeneity, whereas peak postoperative CRP during hospitalization yielded a highly consistent and significant effect (HR:1.53, 95% CI:1.34-1.76). Notably, peak CRP measured within the first week after surgery served as an independent prognostic factor for both worse OS (HR:1.80, 95% CI:1.38-2.34) and RFS (HR:1.63, 95% CI:1.29-2.06) after multivariable adjustment, without heterogeneity.
conclusionThis study identifies postoperative CRP as a powerful and readily available prognostic indicator for patients undergoing radical gastrectomy for gastric cancer, with its peak level within the first postoperative week being of particular prognostic value. Future prospective studies should aim to establish the optimal timing and specific thresholds for postoperative CRP measurement, thereby facilitating its effective integration into routine clinical practice.
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