Observational studyBMC medical imaging2025
Qualitative and quantitative assessment of accelerated liver diffusion-weighted imaging using deep-learning reconstruction in oncologic patients.
Observational study in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05118555 (Evaluation of New Magnetic Resonance Techniques), which is not on this map. Not yet cited in PubMed.
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Evaluation of New Magnetic Resonance Techniques
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9 authors.
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Abstract
backgroundDeep-learning (DL) reconstructions could improve image quality and reduce acquisition time in diffusion-weighted imaging (DWI). This study assessed, qualitatively and quantitatively, DL-DWI in liver metastasis of colorectal cancer patients.
methodsThis prospective study enrolled 50 participants from June to November 2022. Phantom and participant data were acquired on a 1.5T MR scanner using a free-breathing DL-DWI research application sequence. Three DWIs were compared: a moderately-accelerated DL-DWI (DL-1), a corresponding standard reconstruction (Standard-1) and a highly-accelerated DL-DWI (DL-2). Image quality (four features on b750 images and one feature on ADC map) was assessed by two radiologists. Region of interest (ROI) based ADC measurements were performed at three locations: liver, spleen, liver metastasis. Across the three series, median scores and ADC values were assessed using a Friedman non-parametric test and post-hoc analysis (pairwise Wilcoxon tests with Bonferroni correction). A p-value < 0.05 was considered statistically significant.
resultsFifty participants with metastatic colorectal cancer (mean age 62 years, range 36-88 years, 26 males) were evaluated. ROIs were delineated in liver (N = 50), spleen (N = 48), and liver metastasis (N = 11). Qualitatively, across both readers, DL-1 method received the highest scores for 5/8 features on the b750 images; all methods scored similarly on ADC maps for both readers. Quantitatively, ADCs were significantly different between DL-1 and Standard-1 series across all three organs, with DL-1-based ADC always higher (p < 0.01). This ADC increase was small: 8.9% (liver), 3.4% (spleen), 4.5% (liver metastasis).
conclusionsThis study suggests that a DL-based reconstruction is a promising technique to enable acceleration of liver DWI considering both qualitative and quantitative results.
trial registrationNCT05118555 (Evaluation of New Magnetic Resonance Techniques); study date of registration (first submitted: 2021-10-18).
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