Evidence map›Paper›PMID 41299254›Full record

ReviewBMC cardiovascular disorders2025

Abdominal pain as the sole initial manifestation of ANCA-positive EGPA with myocarditis: a case report and literature review.

Wang Zhongkai, Li Ruijie, Liu Liping, Wu Changyong, Sun Huang, Peng Yunzhu

Erratum issuedAbstract readCase ReportsReview
In one paragraph

Review in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Wang ZhongkaiDepartment of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Li RuijieDepartment of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Liu LipingDepartment of Ultrasound, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Wu ChangyongDepartment of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
Sun HuangDepartment of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China. Sunhuang@ydyy.cn.
Peng YunzhuDepartment of Cardiology, The Affiliated Hospital of Yunnan University, Kunming, China. pengyunzhu0308@163.com.

Funding

Major Project of Yunnan University Medical Research Fund YDYXJJ2024-0001Medical leading Talents Training Program of Yunnan Provincial Health Commission L-2019026
6 · The paper itself

Abstract

backgroundEosinophilic granulomatosis with polyangiitis (EGPA) typically presents with asthma, but we report an anti-neutrophil cytoplasmic antibody (ANCA)-positive EGPA case with an unusual presentation: isolated abdominal pain as the initial manifestation of systemic vasculitis, which progressed rapidly to life-threatening cardiac involvement in the absence of overt respiratory symptoms at onset. CASE PRESENTATION: A 70-year-old female presented with abdominal pain and was found to have eosinophilia with elevated cardiac biomarkers. Despite normal coronary angiography, cardiac magnetic resonance revealed left ventricular hypoperfusion and an apical thrombus, leading to a diagnosis of eosinophilic myocarditis and vasculitis by biopsy. Symptoms and thrombus resolved with glucocorticoids without anticoagulation. Cyclophosphamide was added for persistent cardiac dysfunction.

conclusionsANCA-positive EGPA can present atypically with isolated abdominal pain and rapid cardiac involvement. Therefore, this triad warrants urgent evaluation and early immunosuppression. Thrombus resolution without anticoagulation further supports an inflammation-driven pathology.

Indexed as

Abdominal PainAntibodies, Antineutrophil CytoplasmicChurg-Strauss SyndromeMyocarditisAgedBiopsyCyclophosphamideFemaleGlucocorticoidsHumansImmunosuppressive AgentsThrombosisTreatment OutcomeAntibodies, Antineutrophil CytoplasmicCyclophosphamideGlucocorticoidsImmunosuppressive AgentsCardiac magnetic resonance imagingEchocardiographyEndomyocardial biopsyEosinophilic granulomatosis with polyangiitisEosinophilic myocarditis

Identifiers

PMID41299254
PMCPMC12752052

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.