Evidence map›Paper›PMID 41299246›Full record

ArticleBMC genomics2025

Genomic ancestry and adaptive signatures in the indigenous Hetian cattle from Xinjiang Province of China revealed by whole-genome sequencing.

Xuewei Liu, Tianyong Liu, Yihua Wang, Hong Dong, Fuqiang Li, Xingshan Qi, Yongming Luo, Yi Jiang, Zulfiqar Ahmed, Chuzhao Lei and 1 more

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Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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3citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Xuewei Liu *Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Tianyong Liu *Shanxi Provincial Breeding Sheep Development Corporation Ltd, Jiexiu, 032000, China.
Yihua Wang *Department of Oncology, Taiyuan Central Hospital, Taiyuan, 030000, China.
Hong Dong *Academy of Animal Sciences, Xinjiang Institute of Animal Science, Wulumuqi, 830000, China.
Fuqiang LiHunan Tianhua Industrial Corporation Ltd, Lianyuan, 417100, China.
Xingshan QiAnimal Huabandry Bureau in Biyang County, Biyang, 463700, China.
Yongming LuoAcademy of Animal Sciences, Xinjiang Institute of Animal Science, Wulumuqi, 830000, China.
Yi JiangKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Zulfiqar AhmedDepartment of Livestock and Poultry Production, Faculty of Veterinary and Animal Sciences, University of Poonch Rawalakot, Muzaffarabad, Azad Jammu and Kashmir, 12350, Pakistan.
Chuzhao LeiKey Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
Xiang GuoShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030000, China. guoxiang@sxbqeh.com.cn.

Funding

China Agriculture Research System of MOF and MARA CARS-37National Key R&D Program of China 2023YFD1300100 and 2023YFD1300102Scientific Research Project of the Shanxi Traditional Chinese Medicine Administration 2024ZYY2B023
6 · The paper itself

Abstract

backgroundCattle domestication and subsequent breed formation have profoundly shaped agricultural economies and ecological adaptation worldwide. Among these, Chinese indigenous breeds exhibit extensive phenotypic diversity driven by complex admixture histories. Hetian cattle, a native population from the arid Xinjiang Province of China, possess superior traits including drought tolerance and disease resistance. Despite their ecological and agricultural importance, the genomic architecture and adaptive mechanisms underpinning these traits remain poorly characterized.

resultTo address this gap, we performed whole-genome resequencing of 20 Hetian cattle and integrated comparative analyses with 162 globally representative cattle genomes. We assessed genomic diversity, population structure, and local ancestry using a combination of principal component analysis, admixture modelling, and neighbor-joining phylogenies. Ancestry inference revealed a nearly equal taurine (49.99%) and indicine (50.01%) genetic composition, tracing to an admixture event approximately 38 generations ago. Selection signature analyses using CLR, iHS, and nucleotide diversity metrics identified genomic regions under positive selection associated with immunity (e.g., SLAMF1, CD84), high-altitude adaptation (AGBL4, ALX3), and drought resistance (HNRNPK, XYLT1, ADPGK). Two missense mutations (rs208626726 and rs134151223) within candidate genes may contribute to the physiological resilience of Hetian cattle.

conclusionThis study elucidates the genetic basis of local adaptation in Hetian cattle through comprehensive genomic characterization. The identification of key adaptive loci provides valuable insights into the evolutionary history and environmental resilience of this population. These findings contribute to the conservation genomics of Chinese native cattle and inform molecular breeding strategies aimed at improving adaptation and productivity under climate-stressed agroecosystems.

Indexed as

Adaptation, PhysiologicalGenomicsWhole Genome SequencingAnimalsCattleChinaGenetics, PopulationGenetic VariationGenomePhylogenyPolymorphism, Single NucleotideSelection, GeneticAdaptive evolutionCattle domesticationGenomic diversityHetian cattleIndicine–taurine admixtureLocal ancestry inferenceMissense mutationSelective sweep analysis

Identifiers

PMID41299246
PMCPMC12751780

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