Evidence map›Paper›PMID 41299208›Full record

ArticleMagnetic resonance in medicine2026

OxyTrack: A Novel Needle Sensor for In Situ Oximetry.

Ryan C O'Connell, Maciej M Kmiec, Sergey V Petryakov, Conner S Ubert, Marthony L Robins, Eugene Demidenko, Philip E Schaner, Aharon Blank, Periannan Kuppusamy

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ryan C O'ConnellDepartment of Radiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Maciej M KmiecDepartment of Radiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Sergey V PetryakovDepartment of Radiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Conner S UbertDepartment of Radiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Marthony L RobinsDepartment of Radiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Eugene DemidenkoDepartment of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Philip E SchanerDepartment of Radiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.
Aharon BlankSchulich Faculty of Chemistry, Technion, Israel, Institute of Technology, Haifa, Israel.ORCID https://orcid.org/0000-0003-4056-8103
Periannan KuppusamyDepartment of Radiology, Geisel School of Medicine, Dartmouth College, Hanover, New Hampshire, USA.ORCID https://orcid.org/0000-0002-3214-0660

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
Probes and Methods for Clinical OximetryR01EB004031 · NIBIB · OHIO STATE UNIVERSITY · PI KUPPUSAMY, PERIANNAN · 2004 to 2021
$7.1M
Multimodal Marker for imaging oximetry in radiotherapyR01CA269234 · NCI · DARTMOUTH COLLEGE · PI PERIANNAN KUPPUSAMY · 2023 to 2026
$3.0M
Novel oxygen monitoring system for on-site use in the clinicR01EB036124 · NIBIB · DARTMOUTH COLLEGE · PI PERIANNAN KUPPUSAMY · 2024 to 2026
$949k
NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA269234NIBIB NIH HHS R01 EB004031NIBIB NIH HHS R01 EB036124NIH HHS R01 CA269234NIH HHS R01 EB004031NIH HHS R01 EB036124
6 · The paper itself

Abstract

purposeIn vivo electron paramagnetic resonance (EPR) oximetry is a powerful method for tissue oxygen measurements. OxyChip is an implantable probe that is widely used in animal models and currently being evaluated for use in human subjects. The OxyChip requires an external resonator (RF coil) capable of sufficient depth sensitivity, preferably up to 4 cm or more, which is a limitation for existing resonators. The goal of present study was to develop a novel sensor/device, called OxyTrack, for deep-tissue oximetry.

methodsSeveral OxyTracks consisting of coax-tip micro-loop resonator embedded with OxyChip were designed using various needles (0.5-1 mm outer diameter; 3-17 cm length) and tested using an L-band continuous wave EPR spectrometer.

resultsThe OxyTrack showed high signal-to-noise ratio (SNR) at low RF powers, for example SNR of 86 at 45-nW incident power. The orientation of the sensor with respect to the magnetic field (B

conclusionThe OxyTrack technology represents a significant advancement in the practice of EPR oximetry for in situ monitoring of deep-tissue oxygenation.

Indexed as

NeedlesOximetryOxygenTransducersAnimalsElectron Spin Resonance SpectroscopyEquipment DesignEquipment Failure AnalysisMiceReproducibility of ResultsSensitivity and SpecificityOxygenEppendorf needle electrodeEPREPR instrumentationESR spectroscopyoximetryresonator designtumor hypoxia

Identifiers

PMID41299208
PMCPMC13264483

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.